卡唑洛尔对小猫和非洲爪蟾心室肌中与腺苷酸环化酶偶联的β-肾上腺素能受体具有高亲和力。
High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis.
作者信息
Morris T H, Birnbaumer L, Kaumann A J
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):295-7. doi: 10.1007/BF00498057.
PMID:210404
Abstract
Catecholamine-induced stimulation of adenylyl cyclase in ventricular membranes of kitten and Xenopus laevis was antagonized competitively by carazolol. Apparent equilibrium constants ranging between 100-170 pM were estimated for the beta-adrenoceptor-carazolol complex.
摘要
卡唑洛尔竞争性拮抗了儿茶酚胺诱导的小猫和非洲爪蟾心室膜中腺苷酸环化酶的刺激作用。β-肾上腺素能受体-卡唑洛尔复合物的表观平衡常数估计在100-170 pM之间。
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