在幼猫心室肌中，激动剂的变力作用效能取决于其对腺苷酸环化酶的内在活性及其对β肾上腺素能受体的亲和力。 - Suppr

Suppr

超能文献

In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the beta-adrenoceptors.

作者信息

Kaumann A J

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):13-8. doi: 10.1007/BF00506250.

DOI:10.1007/BF00506250

PMID:6116196

Abstract

摘要

相似文献

In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the beta-adrenoceptors.在幼猫心室肌中，激动剂的变力作用效能取决于其对腺苷酸环化酶的内在活性及其对β肾上腺素能受体的亲和力。

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):13-8. doi: 10.1007/BF00506250.

On minimum cyclic AMP formation rates associated with positive inotropic effects mediated through beta 1-adrenoceptors in kitten myocardium. Beta 1-specific and non-adrenergic stimulant effects of denopamine.关于小猫心肌中通过β1-肾上腺素能受体介导的正性肌力作用相关的最小环磷酸腺苷形成率。多巴胺的β1特异性和非肾上腺素能刺激作用。

Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb;339(1-2):113-28. doi: 10.1007/BF00165133.

Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle.儿茶酚胺和二丁酰环磷腺苷3',5'-单磷酸对心肌的舒张作用。介导儿茶酚胺对小猫乳头肌收缩和舒张作用的β-肾上腺素能受体的相似性。

Naunyn Schmiedebergs Arch Pharmacol. 1977 Feb;296(3):205-15. doi: 10.1007/BF00498687.

Xamoterol activates beta 1- but not beta 2-adrenoceptors in mammalian myocardium: comparison of its affinity for beta 1- and beta 2-adrenoceptors coupled to the adenylate cyclase in feline and human ventricle with positive inotropic effects.扎莫特罗可激活哺乳动物心肌中的β1 - 肾上腺素能受体，但不激活β2 - 肾上腺素能受体：比较其对猫和人心室中与腺苷酸环化酶偶联的β1 - 和β2 - 肾上腺素能受体的亲和力及正性肌力作用。

J Cardiovasc Pharmacol. 1989 Jan;13(1):105-17.

An initial characterization of human heart beta-adrenoceptors and their mediation of the positive inotropic effects of catecholamines.人类心脏β-肾上腺素能受体的初步特征及其对儿茶酚胺正性肌力作用的介导

Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):216-21. doi: 10.1007/BF00495868.

Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521).无氮低亲和力配体3'，4'-二羟基-α-甲基苯丙酮（U-0521）对心肌β-肾上腺素能受体的激活作用。

Naunyn Schmiedebergs Arch Pharmacol. 1977 Feb;296(3):217-28. doi: 10.1007/BF00498688.

A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle.N-异丙基和N-叔丁基取代基对大鼠心房窦房结β-肾上腺素能受体及小猫心室中与腺苷酸环化酶偶联的β-肾上腺素能受体配体亲和力影响的比较。

Naunyn Schmiedebergs Arch Pharmacol. 1979 May;307(1):1-8. doi: 10.1007/BF00506545.

[Cardiac beta receptors--experimental aspects].[心脏β受体——实验方面]

Z Kardiol. 1983 Feb;72(2):63-82.

Positive inotropic effects of methoxamine: evidence for alpha-adrenergic receptors in ventricular myocardium.甲氧明的正性肌力作用：心室心肌中α-肾上腺素能受体的证据。

Am J Physiol. 1975 Sep;229(3):582-5. doi: 10.1152/ajplegacy.1975.229.3.582.

High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis.卡唑洛尔对小猫和非洲爪蟾心室肌中与腺苷酸环化酶偶联的β-肾上腺素能受体具有高亲和力。

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):295-7. doi: 10.1007/BF00498057.

引用本文的文献

Adrenoceptor-mediated effects of optically active catecholimidazolines in pithed rat.光学活性儿茶酚咪唑啉在去大脑大鼠中的肾上腺素能受体介导效应

Naunyn Schmiedebergs Arch Pharmacol. 1983 Jul;323(3):221-7. doi: 10.1007/BF00497667.

Competitive and non-competitive interactions between specific ligands and beta-adrenoceptors in living cardiac cells.特定配体与活心肌细胞中β-肾上腺素能受体之间的竞争性和非竞争性相互作用。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Nov;321(2):89-99. doi: 10.1007/BF00518474.

Analysis of the beta 1 and beta 2 adrenoceptor interactions of the partial agonist, clenbuterol (NAB365), in the rat jugular vein and atria.大鼠颈静脉和心房中部分激动剂克仑特罗（NAB365）的β1和β2肾上腺素能受体相互作用分析。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):145-51. doi: 10.1007/BF00506314.

A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors.布普诺洛尔环去甲基化产生对心肌和气管β-肾上腺素能受体具有高亲和力的部分激动剂（K 105）的部分激动剂浓度依赖性的新分析。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):130-44. doi: 10.1007/BF00506313.

Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):216-21. doi: 10.1007/BF00495868.

3H-(-)-Bupranolol, a new beta-adrenoceptor radioligand: characterization of its binding to kitten heart beta-adrenoceptors.3H-(-)-布普萘洛尔，一种新型β-肾上腺素能受体放射性配体：其与幼猫心脏β-肾上腺素能受体结合特性的研究

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):19-25. doi: 10.1007/BF00506251.

Effects of in vivo treatment with isoprenaline or prenalterol on beta-adrenoceptor mechanisms in the heart and soleus muscle of the cat.体内用异丙肾上腺素或普瑞特罗治疗对猫心脏和比目鱼肌中β-肾上腺素能受体机制的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):251-8. doi: 10.1007/BF00495952.

Cultured heart cells as a model for beta-adrenoceptors in a heart pacemaker. Chronotropic spare beta-adrenoceptors and spare adenylyl cyclase for (-)-isoprenaline but not for (-)-dichloroisoprenaline in rat cardiocytes.培养的心脏细胞作为心脏起搏器中β-肾上腺素能受体的模型。大鼠心肌细胞中对（-）-异丙肾上腺素存在变时性备用β-肾上腺素能受体和备用腺苷酸环化酶，但对（-）-二氯异丙肾上腺素不存在。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):119-29. doi: 10.1007/BF00506312.

On equilibrium dissociation constants for complexes of drug-receptor subtypes. Selective and non-selective interactions of partial agonists with two plausible beta-adrenoceptor subtypes mediating positive chronotropic effects of (-)-isoprenaline in kitten atria.关于药物 - 受体亚型复合物的平衡解离常数。部分激动剂与两种可能的β - 肾上腺素能受体亚型的选择性和非选择性相互作用，这两种亚型介导（ - ） - 异丙肾上腺素对小猫心房的正性变时作用。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Feb;318(3):192-201. doi: 10.1007/BF00500480.

Interactions of three inotropic agents, ASL-7022, dobutamine and dopamine, with alpha- and beta-adrenoceptors in vitro.三种正性肌力药物ASL-7022、多巴酚丁胺和多巴胺在体外与α和β肾上腺素能受体的相互作用。

Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):317-26. doi: 10.1007/BF00501436.

本文引用的文献

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

A modification of receptor theory.受体理论的一种修正。

Br J Pharmacol Chemother. 1956 Dec;11(4):379-93. doi: 10.1111/j.1476-5381.1956.tb00006.x.

Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory.竞争性抑制理论中的亲和力与内在活性。I. 问题与理论

Arch Int Pharmacodyn Ther. 1954 Sep 1;99(1):32-49.

Evidence that (+)-bupranolol interacts directly with myocardial beta-adrenoceptors. Control of optical purity with differential thermal analysis.(+)-布普洛尔与心肌β-肾上腺素能受体直接相互作用的证据。用差示热分析法控制光学纯度。

Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):1-8. doi: 10.1007/BF00505796.

Stimulation by adrenaline and dopamine but not by noradrenaline of myocardial alpha-adrenoceptors mediating positive inotropic effects in human atrial preparations.肾上腺素和多巴胺可刺激人心房组织中介导正性肌力作用的心肌α-肾上腺素能受体，而去甲肾上腺素则无此作用。

Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):99-102. doi: 10.1007/BF00502581.

Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1.异丙肾上腺素和前列腺素E1对颗粒型环磷酸腺苷依赖性蛋白激酶的选择性激活作用。

J Biol Chem. 1980 Jun 10;255(11):5113-9.

beta-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: dissociation of stimulation and blockade.β-肾上腺素能受体阻断剂在离体心肌中作为部分激动剂：刺激与阻断的解离

Naunyn Schmiedebergs Arch Pharmacol. 1980 Apr;311(3):237-48. doi: 10.1007/BF00569403.

Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol.β-肾上腺素受体阻断剂作为离体心肌中简单竞争性拮抗剂的比较评估：对异丙肾上腺素的变力性和变时性阻断效能的相似性

Naunyn Schmiedebergs Arch Pharmacol. 1980 Apr;311(3):219-36. doi: 10.1007/BF00569402.

Iodohydroxybenzylpindolol: preparation, purification, localization of its iodine to the indole ring, and characterization as a partial agonist.碘羟基苄基吲哚洛尔：制备、纯化、其碘在吲哚环上的定位以及作为部分激动剂的特性

Mol Pharmacol. 1980 May;17(3):328-38.

Convenient apparatus for recording contractions of isolated heart muscle.用于记录离体心肌收缩的便捷仪器。

J Appl Physiol. 1965 Jul;20(4):755-7. doi: 10.1152/jappl.1965.20.4.755.

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