N-异丙基和N-叔丁基取代基对大鼠心房窦房结β-肾上腺素能受体及小猫心室中与腺苷酸环化酶偶联的β-肾上腺素能受体配体亲和力影响的比较。 - Suppr

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超能文献

A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle.

作者信息

Kaumann A J, Morris T H, Birnbaumer L

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1979 May;307(1):1-8. doi: 10.1007/BF00506545.

DOI:10.1007/BF00506545

PMID:39258

Abstract

摘要

相似文献

A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial beta-adrenoceptors in rat atria and beta-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle.N-异丙基和N-叔丁基取代基对大鼠心房窦房结β-肾上腺素能受体及小猫心室中与腺苷酸环化酶偶联的β-肾上腺素能受体配体亲和力影响的比较。

Naunyn Schmiedebergs Arch Pharmacol. 1979 May;307(1):1-8. doi: 10.1007/BF00506545.

Direct labelling of myocardial beta 1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.心肌β1-肾上腺素能受体的直接标记。3H-（-）-比索洛尔结合亲和力与其阻断效能的比较。

Naunyn Schmiedebergs Arch Pharmacol. 1985 Oct;331(1):27-39. doi: 10.1007/BF00498849.

Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521).无氮低亲和力配体3'，4'-二羟基-α-甲基苯丙酮（U-0521）对心肌β-肾上腺素能受体的激活作用。

Naunyn Schmiedebergs Arch Pharmacol. 1977 Feb;296(3):217-28. doi: 10.1007/BF00498688.

Structure-binding-activity analysis of beta-adrenergic amines--I. Binding to the beta receptor and activation of adenylate cyclase.β-肾上腺素能胺的结构-结合-活性分析——I. 与β受体的结合及腺苷酸环化酶的激活

Biochem Pharmacol. 1978 May 15;27(10):1445-54. doi: 10.1016/0006-2952(78)90100-4.

The beta adrenergic receptors of rat corpus luteum membranes.大鼠黄体膜的β-肾上腺素能受体

Biochem Pharmacol. 1979 Apr 1;28(7):1003-10. doi: 10.1016/0006-2952(79)90294-6.

High affinity of carozolol for beta-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and Xenopus laevis.卡唑洛尔对小猫和非洲爪蟾心室肌中与腺苷酸环化酶偶联的β-肾上腺素能受体具有高亲和力。

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):295-7. doi: 10.1007/BF00498057.

In kitten ventricular myocardium, the inotropic potency of an agonist is determined by both its intrinsic activity for the adenylyl cyclase and its affinity for the beta-adrenoceptors.在幼猫心室肌中，激动剂的变力作用效能取决于其对腺苷酸环化酶的内在活性及其对β肾上腺素能受体的亲和力。

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):13-8. doi: 10.1007/BF00506250.

3H-(-)-Bupranolol, a new beta-adrenoceptor radioligand: characterization of its binding to kitten heart beta-adrenoceptors.3H-(-)-布普萘洛尔，一种新型β-肾上腺素能受体放射性配体：其与幼猫心脏β-肾上腺素能受体结合特性的研究

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):19-25. doi: 10.1007/BF00506251.

Structure-binding-activity analysis of beta-adrenergic amines--II. Binding to the beta receptor and inhibition of adenylate cyclase.β-肾上腺素能胺的结构-结合-活性分析——II. 与β受体的结合及对腺苷酸环化酶的抑制作用

Biochem Pharmacol. 1978 May 15;27(10):1455-61. doi: 10.1016/0006-2952(78)90101-6.

Interchange of adenyl and guanyl cyclases as an explanation for transformation of Beta- to alpha-adrenergic responses in the rat atrium.腺苷酸环化酶与鸟苷酸环化酶的互换作为大鼠心房β-肾上腺素能反应转变为α-肾上腺素能反应的一种解释。

Nature. 1975 Jul 31;256(5516):421-4. doi: 10.1038/256421a0.

引用本文的文献

Differences between the third cardiac beta-adrenoceptor and the colonic beta 3-adrenoceptor in the rat.大鼠心脏第三种β-肾上腺素能受体与结肠β3-肾上腺素能受体之间的差异

Br J Pharmacol. 1996 Aug;118(8):2085-98. doi: 10.1111/j.1476-5381.1996.tb15648.x.

Expression of beta 3-adrenoceptor mRNA in rat tissues.大鼠组织中β3-肾上腺素能受体mRNA的表达。

Br J Pharmacol. 1996 Jan;117(1):210-6. doi: 10.1111/j.1476-5381.1996.tb15176.x.

Competitive and non-competitive interactions between specific ligands and beta-adrenoceptors in living cardiac cells.特定配体与活心肌细胞中β-肾上腺素能受体之间的竞争性和非竞争性相互作用。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Nov;321(2):89-99. doi: 10.1007/BF00518474.

A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors.布普诺洛尔环去甲基化产生对心肌和气管β-肾上腺素能受体具有高亲和力的部分激动剂（K 105）的部分激动剂浓度依赖性的新分析。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):130-44. doi: 10.1007/BF00506313.

An initial characterization of human heart beta-adrenoceptors and their mediation of the positive inotropic effects of catecholamines.人类心脏β-肾上腺素能受体的初步特征及其对儿茶酚胺正性肌力作用的介导

Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):216-21. doi: 10.1007/BF00495868.

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):19-25. doi: 10.1007/BF00506251.

Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles.N-叔丁基衍生物β-肾上腺素能阻滞剂对豚鼠乳头肌动作电位最大上升速度的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(1):50-7. doi: 10.1007/BF00647838.

Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):13-8. doi: 10.1007/BF00506250.

Comparative assessment of beta-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: similarity of inotropic and chronotropic blocking potencies against isoproterenol.β-肾上腺素受体阻断剂作为离体心肌中简单竞争性拮抗剂的比较评估：对异丙肾上腺素的变力性和变时性阻断效能的相似性

Naunyn Schmiedebergs Arch Pharmacol. 1980 Apr;311(3):219-36. doi: 10.1007/BF00569402.

Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation.吲哚洛尔光学异构体对豚鼠窦房结和气管的兴奋及阻断作用。β-肾上腺素能受体亚型在阻断与兴奋解离中的作用。

Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):159-75. doi: 10.1007/BF00500912.

本文引用的文献

The comparative pharmacology of the N-alkyl-arterenols.N-烷基去甲肾上腺素的比较药理学

J Pharmacol Exp Ther. 1948 Feb;92(2):108-20.

A study of the adrenotropic receptors.促肾上腺受体的研究。

Am J Physiol. 1948 Jun;153(3):586-600. doi: 10.1152/ajplegacy.1948.153.3.586.

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

A NEW ADRENERGIC BETARECEPTOR ANTAGONIST.一种新型肾上腺素能β受体拮抗剂。

Lancet. 1964 May 16;1(7342):1080-1. doi: 10.1016/s0140-6736(64)91275-9.

Pharmacology of a new adrenergic beta-receptor-blocking compound (Nethalide).一种新型肾上腺素能β受体阻滞剂化合物（奈他洛尔）的药理学

Lancet. 1962 Aug 18;2(7251):311-4. doi: 10.1016/s0140-6736(62)90103-4.

Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。

Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.

Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.异丙肾上腺素的二氯类似物对哺乳动物心脏的肾上腺素能阻滞作用。

J Pharmacol Exp Ther. 1958 Nov;124(3):223-37.

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.异丙肾上腺素的二氯类似物对抑制性肾上腺素能受体的阻断作用。

J Pharmacol Exp Ther. 1958 Apr;122(4):480-8.

A modification of receptor theory.受体理论的一种修正。

Br J Pharmacol Chemother. 1956 Dec;11(4):379-93. doi: 10.1111/j.1476-5381.1956.tb00006.x.

Pharmacological properties of H 56-28--a beta-adrenergic receptor antagonist.H 56-28的药理学特性——一种β-肾上腺素能受体拮抗剂。

Acta Pharmacol Toxicol (Copenh). 1967;25:9-40.

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