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喉利什曼病作为慢性喉炎的病因

[Leishmaniasis isolated to the larynx as cause of chronic laryngitis].

作者信息

Kaltoft Mikkel, Munch-Petersen Helga Richert, Møller Henrik

机构信息

Gentofte Hospital, Øre-naese-halskirurgisk Afdeling E, Denmark.

出版信息

Ugeskr Laeger. 2010 Oct 18;172(42):2898-9.

Abstract

Mucosal leishmaniasis is uncommon outside Central and South America, where it is commonly caused by Leishmania (L.) braziliensis. We present a case of isolated laryngeal leishmaniasis detected in a 78-year-old male, who presented with chronic hoarseness. Histologic examination of biopsies taken from the larynx showed L. amastigotes. An L.-specific indirect fluorescent antibody test was positive. Polymerase chain reaction showed infection with L. donovani, L. infantum or L. tropica, species which do not normally cause isolated mucosal infection. This is the first reported case from Scandinavia.

摘要

黏膜利什曼病在中美洲和南美洲以外地区并不常见,在这些地区通常由巴西利什曼原虫(Leishmania (L.) braziliensis)引起。我们报告一例在一名78岁男性中检测到的孤立性喉利什曼病病例,该患者表现为慢性声音嘶哑。对喉部活检组织进行的组织学检查显示有无鞭毛体。利什曼原虫特异性间接荧光抗体试验呈阳性。聚合酶链反应显示感染了杜氏利什曼原虫、婴儿利什曼原虫或热带利什曼原虫,这些物种通常不会引起孤立性黏膜感染。这是斯堪的纳维亚半岛报道的首例病例。

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