Andersen Jakob Hessel, Olsen Karsten Skovgaard
Surgery and Anaesthesiology Department Y, Glostrup Hospital, 2600 Glostrup, Denmark.
Dan Med Bull. 2010 Oct;57(10):A4194.
Awake craniotomy for tumour resection has been performed at Glostrup Hospital since 2004. We describe and discuss the various anaesthetic approaches for such surgery and retrospectively analyse the 44 planned awake craniotomies performed at Glostrup Hospital. The surgery falls into four phases: craniotomy, mapping, tumour resection and closing. Three methods are being used: monitored anaesthetic care, asleep-awake-asleep and asleep-awake (AA).
Anaesthesia is induced and maintained with propofol and remifentanil. A laryngeal mask (LM) is used as an airway during the craniotomy phase. In the AA method, patients are mapped and the tumour is resected while the patient is awake.
A total of 41 of 44 planned AA craniotomies were performed. Three had to be converted into general anaesthesia (GA) due to tight brain, leaking LM and tumour haemorrhage, respectively. The following complications were observed: bradycardia 10%, leaking LM 5%, nausea 10%, vomiting 5%, focal seizures 28%, generalized seizures 10%, hypoxia 2%, hypotension 5% and hypertension 2%.
Our results comply well with the international literature in terms of complications related to haemodynamics, respiration, seizures, vomiting and nausea and in terms of patient satisfaction. Awake craniotomy is a well-tolerated procedure with potential benefits. More prospective randomized studies are required.
自2004年以来,格罗斯特鲁普医院一直开展清醒开颅肿瘤切除术。我们描述并讨论了此类手术的各种麻醉方法,并对格罗斯特鲁普医院实施的44例计划清醒开颅手术进行了回顾性分析。该手术分为四个阶段:开颅、脑图谱绘制、肿瘤切除和缝合。目前使用三种方法:麻醉监测、清醒-睡眠-清醒和清醒-清醒(AA)。
采用丙泊酚和瑞芬太尼诱导并维持麻醉。在开颅阶段使用喉罩(LM)作为气道。在AA方法中,患者在清醒状态下进行脑图谱绘制和肿瘤切除。
44例计划的AA开颅手术中,共实施了41例。3例分别因脑紧绷、喉罩漏气和肿瘤出血而改为全身麻醉(GA)。观察到以下并发症:心动过缓10%、喉罩漏气5%、恶心10%、呕吐5%、局灶性癫痫发作28%、全身性癫痫发作10%、低氧血症2%、低血压5%和高血压2%。
在与血流动力学、呼吸、癫痫发作、呕吐和恶心相关的并发症以及患者满意度方面,我们的结果与国际文献相符。清醒开颅手术耐受性良好,具有潜在益处。需要更多前瞻性随机研究。