Department of Anatomy and Histology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy.
J Ethnopharmacol. 2011 Jan 27;133(2):629-33. doi: 10.1016/j.jep.2010.10.058. Epub 2010 Oct 30.
Satureja montana (winter savory) is a medicinal plant traditionally used to treat different disorders including male sexual dysfunction. In this study we evaluated the effect of Satureja montana hydroalcoholic extract on copulatory behavior of sexually potent male rats.
The extract was orally administered acutely or repetitively for 8 consecutive days at the doses of 25 and 50 mg/kg. The main parameters of sexual behavior, mount (ML), intromission (IL), ejaculation (EL) latencies and post-ejaculatory interval (PEI), were evaluated in animals submitted to mating test and multiple ejaculations test. Testosterone serum levels were measured in rats acutely treated with Satureja montana extract dosed at 50 mg/kg. In addition the open field test was conducted to evaluate the locomotor behavior.
When acutely administered at both dosages, the extract was able to significantly increase EL and decrease intromission frequency (IF) in comparison with controls. The significant increase in EL was found also when the extract was subacutely administered, daily for 8 consecutive days, at the dose of 25 mg/kg. In the multiple ejaculations test, EL values of treated rats were significantly increased during the 1st and 2nd sequence in comparison with controls; in addition only rats treated with the extract were able to reach the 4th ejaculation within 30 min. Testosterone serum level measured in rats acutely treated with Satureja montana at the dose of 50 mg/kg was significantly increased in rats in comparison with controls. Finally, the locomotor activity recorded in the open field test was not affected by the acute administration of the plant extract.
These data suggest that Satureja montana could be considered as a natural remedy for the treatment of premature ejaculation delaying ejaculation latency without exerting any negative effect on the other parameters of sexual behavior and without exerting a sedative effect. In addition the increased serum level of testosterone confirms the positive influence of Satureja montana on male sexual function.
冬香薄荷（冬香薄荷）是一种药用植物，传统上用于治疗多种疾病，包括男性性功能障碍。在这项研究中，我们评估了冬香薄荷水醇提取物对有性能力的雄性大鼠交配行为的影响。
提取物以 25 和 50mg/kg 的剂量分别连续 8 天口服急性或重复给药。在动物交配试验和多次射精试验中，评估了主要的性行为参数，即交配（ML）、插入（IL）、射精（EL）潜伏期和射精后间隔（PEI）。雄性大鼠经急性给予冬香薄荷提取物 50mg/kg 后，测定血清睾酮水平。此外，还进行了旷场试验以评估运动行为。
当以两种剂量急性给予时，提取物可显著增加 EL 并降低与对照组相比的插入频率（IF）。当提取物以亚急性方式给予时，即每天连续 8 天给予 25mg/kg 时，也发现 EL 显著增加。在多次射精试验中，与对照组相比，治疗组大鼠在第 1 和第 2 个序列中的 EL 值显著增加；此外，只有用提取物治疗的大鼠才能在 30 分钟内达到第 4 次射精。与对照组相比，急性给予 50mg/kg 冬香薄荷提取物的大鼠血清睾酮水平显著升高。最后，急性给予植物提取物对旷场试验中的运动活性没有影响。
这些数据表明，冬香薄荷可被视为治疗早泄的天然药物，可延迟射精潜伏期，而对其他性行为参数没有任何负面影响，也没有镇静作用。此外，血清睾酮水平的升高证实了冬香薄荷对男性性功能的积极影响。
