Maxton D G, Whorwell P J
Department of Medicine, University Hospital of South Manchester, UK.
Aliment Pharmacol Ther. 1990 Jun;4(3):305-8. doi: 10.1111/j.1365-2036.1990.tb00475.x.
Intravenous nicardipine has previously been shown to abolish the effect of a 1000-calorie meal on colonic motility. The purpose of this study was to use the same experimental design to assess the effect of nicardipine instilled directly into the colon. Each patient was studied three times when receiving either placebo, 15 mg or 30 mg nicardipine infused over 2 h. Blood concentrations of nicardipine remained very low, but neither dose of the drug affected either basal or post-prandial colonic motility. Topical nicardipine does not appear to have therapeutic potential and its activity is probably dependent on systemic absorption.
先前的研究表明，静脉注射尼卡地平可消除1000卡路里餐食对结肠动力的影响。本研究的目的是采用相同的实验设计，评估直接注入结肠的尼卡地平的效果。每位患者在接受安慰剂、2小时内输注15毫克或30毫克尼卡地平时均接受了三次研究。尼卡地平的血药浓度一直很低，但两种剂量的药物均未影响基础或餐后结肠动力。局部应用尼卡地平似乎没有治疗潜力，其活性可能依赖于全身吸收。
