Soifer L, Varela E, Olmos J
Servicio de Gastroenterología, Hospital Italiano, Buenos Aires.
Acta Gastroenterol Latinoam. 1992;22(1):37-43.
The effects of pinaverium bromide on colonic motility were investigated in a controlled, controlled, cross-over study in 32 patients with irritable bowel syndrome. Constipation was clearly predominant in one group of 16 patients, and diarrhea in the other group of 16. Manometric measurements were taken of the colonic motor response generated by distention of a balloon inserted to the rectosigmoid junction. Measurements were taken before and one hour after ingestion of two tablets containing placebo or two tablets each containing 50 mg of pinaverium bromide. Following intake of placebo the motility index increased from the basal value in patients with constipation, and resistance to distention decreased in the diarrhea group. These changes were attributable to repetition of the mechanical stimulus within a relatively brief time lapse, or more probably to the ingestion of liquid which accompanied intake of tablets. Compared with placebo, pinaverium bromide induced inhibition of both effects. From the therapeutic point of view, the decrease in motility index seen in patients with irritable bowel syndrome and constipation is particularly interesting.
在一项针对32名肠易激综合征患者的对照交叉研究中，研究了匹维溴铵对结肠动力的影响。在16名患者组成的一组中便秘明显占主导，而在另一组16名患者中腹泻占主导。通过插入直肠乙状结肠交界处的气囊扩张所产生的结肠运动反应进行测压测量。在摄入两片含安慰剂的片剂或两片各含50毫克匹维溴铵的片剂之前及之后1小时进行测量。摄入安慰剂后，便秘患者的动力指数从基础值升高，腹泻组对扩张的阻力降低。这些变化归因于在相对较短的时间间隔内重复机械刺激，或者更可能归因于伴随片剂摄入的液体摄入。与安慰剂相比，匹维溴铵抑制了这两种效应。从治疗角度来看，肠易激综合征和便秘患者中动力指数的降低尤其令人关注。
