静脉注射尼卡地平对肠易激综合征患者结肠动力的影响
Reduction of colonic motility by intravenous nicardipine in irritable bowel syndrome.
作者信息
Prior A, Harris S R, Whorwell P J
机构信息
Department of Medicine, University Hospital of South Manchester.
出版信息
Gut. 1987 Dec;28(12):1609-12. doi: 10.1136/gut.28.12.1609.
Abstract
The effect of nicardipine, a new dihydropyridine calcium antagonist, on postprandial colonic motility was assessed in 10 patients with irritable bowel syndrome. Each patient was studied twice receiving intravenously either N saline or nicardipine after a 1000 calorie meal. In the control study there was a significant (p less than 0.01) postprandial increase in the contractile activity of the colon, reaching a peak at approximately 20 minutes. Intravenous nicardipine completely abolished the colonic response, with a significant reduction in the number (p less than 0.005) and amplitude (p less than 0.005) of contractions and of the motility index (p less than 0.025). These results support the need for further studies to evaluate the therapeutic role of nicardipine in the irritable bowel syndrome.
摘要
在10例肠易激综合征患者中评估了新型二氢吡啶类钙拮抗剂尼卡地平对餐后结肠动力的影响。每位患者均接受两次研究，在进食1000卡路里餐食后，分别静脉注射生理盐水或尼卡地平。在对照研究中，餐后结肠收缩活动显著增加（p<0.01），约20分钟时达到峰值。静脉注射尼卡地平完全消除了结肠反应，收缩次数（p<0.005）、收缩幅度（p<0.005）和动力指数（p<0.025）均显著降低。这些结果支持进一步研究以评估尼卡地平在肠易激综合征中的治疗作用。
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