University of Virginia, Dept. of Biomedical Engineering, Charlottesville, VA, USA.
IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Nov;57(11):2437-49. doi: 10.1109/TUFFC.2010.1710.
Bias and variance errors in motion estimation result from electronic noise, decorrelation, aliasing, and inherent algorithm limitations. Unlike most error sources, decorrelation is coherent over time and has the same power spectrum as the signal. Thus, reducing decorrelation is impossible through frequency domain filtering or simple averaging and must be achieved through other methods. In this paper, we present a novel motion estimator, termed the principal component displacement estimator (PCDE), which takes advantage of the signal separation capabilities of principal component analysis (PCA) to reject decorrelation and noise. Furthermore, PCDE only requires the computation of a single principal component, enabling computational speed that is on the same order of magnitude or faster than the commonly used Loupas algorithm. Unlike prior PCA strategies, PCDE uses complex data to generate motion estimates using only a single principal component. The use of complex echo data is critical because it allows for separation of signal components based on motion, which is revealed through phase changes of the complex principal components. PCDE operates on the assumption that the signal component of interest is also the most energetic component in an ensemble of echo data. This assumption holds in most clinical ultrasound environments. However, in environments where electronic noise SNR is less than 0 dB or in blood flow data for which the wall signal dominates the signal from blood flow, the calculation of more than one PC is required to obtain the signal of interest. We simulated synthetic ultrasound data to assess the performance of PCDE over a wide range of imaging conditions and in the presence of decorrelation and additive noise. Under typical ultrasonic elasticity imaging conditions (0.98 signal correlation, 25 dB SNR, 1 sample shift), PCDE decreased estimation bias by more than 10% and standard deviation by more than 30% compared with the Loupas method and normalized cross-correlation with cosine fitting (NC CF). More modest gains were observed relative to spline-based time delay estimation (sTDE). PCDE was also tested on experimental elastography data. Compressions of approximately 1.5% were applied to a CIRS elastography phantom with embedded 10.4-mm-diameter lesions that had moduli contrasts of -9.2, -5.9, and 12.0 dB. The standard deviation of displacement estimates was reduced by at least 67% in homogeneous regions at 35 to 40 mm in depth with respect to estimates produced by Loupas, NC CF, and sTDE. Greater improvements in CNR and displacement standard deviation were observed at larger depths where speckle decorrelation and other noise sources were more significant.
运动估计中的偏差和方差误差源于电子噪声、去相关、混叠和固有算法限制。与大多数误差源不同,去相关在时间上是相干的,并且具有与信号相同的功率谱。因此,通过频域滤波或简单的平均无法减少去相关,必须通过其他方法实现。在本文中,我们提出了一种新颖的运动估计器,称为主成分位移估计器(PCDE),它利用主成分分析(PCA)的信号分离能力来拒绝去相关和噪声。此外,PCDE 仅需要计算单个主成分,从而实现与常用的 Loupas 算法相同数量级或更快的计算速度。与先前的 PCA 策略不同,PCDE 使用复数数据仅使用单个主成分生成运动估计。使用复数回波数据至关重要,因为它允许根据运动分离信号分量,这通过复数主成分的相位变化来揭示。PCDE 的工作假设是,感兴趣的信号分量也是回声数据集合中最具能量的分量。在大多数临床超声环境中,这一假设成立。然而,在电子噪声 SNR 小于 0dB 的环境中,或者在壁信号主导血流信号的血流数据中,需要计算多个 PC 才能获得感兴趣的信号。我们模拟了合成超声数据,以在广泛的成像条件下评估 PCDE 的性能,并在存在去相关和附加噪声的情况下进行评估。在典型的超声弹性成像条件下(信号相关系数为 0.98、信噪比为 25dB、样本移动 1 个),与 Loupas 方法和余弦拟合归一化互相关(NC CF)相比,PCDE 降低了 10%以上的估计偏差和 30%以上的标准差。与基于样条的时移估计(sTDE)相比,观测到的增益较小。PCDE 还在实验弹性成像数据上进行了测试。在 CIRS 弹性体模型中施加了约 1.5%的压缩,该模型中嵌入了 10.4mm 直径的病变,其模量对比度为-9.2、-5.9 和 12.0dB。与 Loupas、NC CF 和 sTDE 产生的估计相比,在 35 到 40mm 深度的均匀区域,位移估计的标准差至少降低了 67%。在深度较大的情况下,由于散斑去相关和其他噪声源更为显著,因此观察到 CNR 和位移标准差的更大改善。