Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Hum Exp Toxicol. 2011 Feb;30(2):160-4. doi: 10.1177/0960327110388539. Epub 2010 Nov 1.
Carbon monoxide poisoning (COP) is one of the important causes of morbidity and mortality in toxicological cases. In this study, we aimed to find out more about the pathophysiology of COP by investigating the effects of COP on oxidative stress parameters such as total oxidant status (TOS) and total antioxidant status (TAS).
Eighty-eight patients admitted to the emergency department of our hospital with acute COP and 35 healthy adults as control group were included in this study. Blood samples were collected from all COP patients at the time of initial emergency department evaluation to determine the oxidative stress parameters. Then, serum levels of total antioxidant status and total oxidant status levels were measured.
A total of 88 patients poisoned by carbon monoxide (CO; mean age 37.1 ± 18.2 years; 54'% women) were enrolled. TOS and carboxyhemoglobin (COHb) levels in COP patients were increased when compared to control group (p = 0.001). TOS, oxidative stress index (OSI) and COHb levels in COP patients were significantly lower after the treatment. (respectively, p = 0.016; p = 0.023; p = 0.001). On the other hand, no statistical differences were observed in TAS levels of study and control group as well as there were no changes with treatment.
Measurements of TOS, TAS and OSI levels may be useful markers to find out the pathophsiology of COP.
一氧化碳中毒（COP）是毒理学病例中发病率和死亡率的重要原因之一。在这项研究中，我们旨在通过研究 COP 对总氧化剂状态（TOS）和总抗氧化状态（TAS）等氧化应激参数的影响，来更深入地了解 COP 的病理生理学。
本研究纳入了 88 例因急性 COP 而入住我院急诊科的患者和 35 名健康成年人作为对照组。从所有 COP 患者入院初始急诊科评估时采集血样，以确定氧化应激参数。然后，测量血清总抗氧化状态和总氧化剂状态水平。
共纳入 88 例一氧化碳（CO）中毒患者（平均年龄 37.1 ± 18.2 岁，54%为女性）。与对照组相比，COP 患者的 TOS 和碳氧血红蛋白（COHb）水平升高（p = 0.001）。COP 患者治疗后 TOS、氧化应激指数（OSI）和 COHb 水平显著降低（分别为 p = 0.016、p = 0.023、p = 0.001）。另一方面，研究组和对照组的 TAS 水平无统计学差异，治疗前后也无变化。
TOS、TAS 和 OSI 水平的测定可能是了解 COP 病理生理学的有用标志物。
