Kono Kenichi, Ito Yui, Miyazaki Yuichi, Yasumori Kotaro, Yasaka Masahiro, Okada Yasushi, Nagata Shinji
Department of Neurosurgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Wakayama-city, Wakayama, Japan.
No Shinkei Geka. 2010 Oct;38(10):933-7.
The prognosis of symptomatic intracranial artery stenosis (SIAS) by medical treatment is poor. Percutaneous balloon angioplasty (PTA) or stenting is effective for SIAS. However, recently, aggressive medical intervention (AMI) has progressed and some drugs have been reported to improve stenosis or prevent the progression of stenosis. We describe a case where combination of PTA and the AMI improved symptomatic basilar artery stenosis with a tortuous access route.
A 78-year-old man was admitted to our hospital suffering from acute brain infarction due to severe basilar artery stenosis. The AMI including cilostazol, statin, and eicosapentaenoic acid failed to prevent recurrence of the brain infarction. We performed PTA and 45% of the residual stenosis remained. We continued the AMI and the stenosis improved to 30% after 3 months.
PTA with minimal risk should be considered for SIAS resistant to AMI. Even if residual stenosis remains, continuation of AMI may prevent recurrence of a brain infarction. The strategy of a combination of PTA with minimal risk and AMI may result in a better prognosis for SIAS.
药物治疗有症状性颅内动脉狭窄(SIAS)的预后较差。经皮球囊血管成形术(PTA)或支架置入术对SIAS有效。然而,近来,积极药物干预(AMI)取得了进展,并且有报道称一些药物可改善狭窄或预防狭窄进展。我们描述了1例通过PTA与AMI联合治疗改善了伴有迂曲入路的有症状基底动脉狭窄的病例。
一名78岁男性因严重基底动脉狭窄导致急性脑梗死入住我院。包括西洛他唑、他汀类药物和二十碳五烯酸在内的AMI未能预防脑梗死复发。我们实施了PTA,术后仍残留45%的狭窄。我们继续进行AMI治疗,3个月后狭窄改善至30%。
对于对AMI耐药的SIAS,应考虑采用风险最小的PTA治疗。即使残留狭窄仍存在,继续进行AMI治疗可能预防脑梗死复发。将风险最小的PTA与AMI联合应用的策略可能会使SIAS患者获得更好的预后。