Studies on biochemical changes in subacute thiodicarb toxicity in rats.

Effect of thiodicarb was investigated on various biochemical parameters and blood enzymes in adult male Wistar rats following its intraperitoneal administration at rates of 2.9 and 5.8 mg/kg daily for 28 days. Rats did not exhibit any marked changes in their gross behavioral signs and symptoms. Thiodicarb caused hyperglycemia in rats; however, increase in plasma glucose level was nonsignificant. There was no effect on total plasma protein indicating no severe damage to vital organs and no interference with protein metabolism in rats. Thiodicarb did not cause significant change in blood urea and creatinine levels, thus indicating to have no toxic effect on kidneys in rats. It did not affect aspartate aminotransferase (AST) level except a significant increase in AST level only on 7th day of treatment. There was an increase in the levels of alanine aminotransferase (ALT), but this trend reversed on 14th and 28th day. Thiodicarb did not alter significantly the levels of alkaline phosphatase in rats. It caused inhibition of plasma and brain acetylcholinesterase (AChE) in rats throughout the entire period of 28 days of treatment, which was dose-dependent. The findings of this investigation indicated that thiodicarb did not effect or alter much the various biochemical profiles except inhibiting AChE following i.p. administration up to 28 days in adult male rats.