酸橙汁对华法林抗凝作用的影响评估。
Evaluation of the effect of lime fruit juice on the anticoagulant effect of warfarin.
作者信息
Adepoju Gka, Adeyemi T
机构信息
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
出版信息
J Young Pharm. 2010 Jul;2(3):269-72. doi: 10.4103/0975-1483.66808.
AIM
Citrus aurantifolia (Family Rutaceae) is commonly known as a familiar food and medicine, and s therapeutic effectiveness in a variety of diseases has been suggested in traditional medicine. Various complementary and alternative medicines (CAM) have been shown to interact with orthodox medicines. Hence, the aim of this study is to investigate such a phenomenon particularly the interaction of lime fruit juice with warfarin.
MATERIALS AND METHOD
Wistar strain albino rats of both sexes weighing between 190 and 230g were administered with oral doses of the respective drugs used depending on the groups of animals. Effects on the anticoagulant activity of warfarin were determined by standard laboratory methods.
RESULT
Lime fruit juice caused a reduction in the anticoagulant activity of warfarin.
CONCLUSION
This finding has shown that CAM can interact with orthodox medicines hence, warfarin prescribers need to be aware of the usage of CAM and monitor the international normalized ratio (INR) of their patients more frequently.
目的
酸橙（芸香科）是一种常见的药食两用植物，传统医学认为其对多种疾病具有治疗作用。多种补充和替代医学（CAM）已被证明会与传统药物相互作用。因此，本研究旨在调查这一现象，特别是酸橙汁与华法林的相互作用。
材料与方法
选取体重在190至230克之间的Wistar品系白化大鼠，根据动物分组给予相应药物口服剂量。通过标准实验室方法测定对华法林抗凝活性的影响。
结果
酸橙汁导致华法林抗凝活性降低。
结论
这一发现表明补充和替代医学可与传统药物相互作用，因此，开具华法林处方的医生需要了解补充和替代医学的使用情况，并更频繁地监测患者的国际标准化比值（INR）。
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