Institute of Public Health, Department of Epidemiology, University of Aarhus.
Clin Epidemiol. 2010 Oct 21;2:229-33. doi: 10.2147/CLEP.S12468.
We examined the association between the number of partners that mothers and fathers have children with and occurrence of cutaneous malignant melanoma (CMM).
We conducted a complete registry-based follow-up of all Danish mothers born after 1935 from the birth of their second child until CMM, death, emigration, or end of study in 2002. We conducted a similar follow-up of the corresponding fathers. Incidence rate ratios (IRR) and confidence intervals (CI) were estimated by Poisson regression.
THIS STUDY CORROBORATES THAT WOMEN HAVING CHILDREN WITH THREE OR MORE MEN ARE HALF AS LIKELY TO HAVE CMM AS WOMEN WHO HAVE CHILDREN WITH ONE MAN: incidence rate ratio (IRR) = 0.51, 95% CI: 0.29, 0.91; having children by two fathers reduces risk among women by 20%: IRR = 0.80, 95% CI: 0.70, 0.91. Fathers with multiple partners tend to face a similar risk reduction.
The similar patterns of mothers and fathers challenge us to consider and propose likely mechanisms common to both sexes. The patterns of reduced risk have now been reported in two large independent complete population-based studies in Sweden and Denmark.
我们研究了母亲和父亲与子女发生性关系的伴侣数量与皮肤恶性黑色素瘤（CMM）发病之间的关联。
我们对所有于 1935 年后出生的丹麦母亲进行了基于登记的完整随访，随访时间从她们的第二个孩子出生开始，直到发生 CMM、死亡、移民或 2002 年研究结束。我们对相应的父亲也进行了类似的随访。通过泊松回归估计发病率比（IRR）和置信区间（CI）。
这项研究证实，与与一个男人育有子女的女性相比，与三个或更多男人育有子女的女性发生 CMM 的可能性降低一半：发病率比（IRR）=0.51，95%置信区间：0.29，0.91；与两个父亲生育子女会使女性的风险降低 20%：IRR=0.80，95%置信区间：0.70，0.91。有多个伴侣的父亲也倾向于面临类似的风险降低。
母亲和父亲的相似模式使我们不得不考虑并提出可能适用于两性的共同机制。这些降低风险的模式现已在瑞典和丹麦的两项独立的大型基于人群的完整研究中得到报道。
