Li X, Hemminki K
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden.
Eur J Cancer Prev. 2003 Oct;12(5):355-8. doi: 10.1097/00008469-200310000-00002.
We used the nation-wide Swedish Family-Cancer Database to analyse cancer risks in men who had had children with more than one woman. Cancer cases were retrieved from the Swedish Cancer Registry from years 1961-1998. A total of 2.9 million men and 298,134 cancer cases were covered. For men having children with two, three or more women, increasing risk trends were shown for upper aerodigestive tract, lung, urinary bladder and oesophageal cancers. Decreasing trends were observed for tumours of the colon, skin (squamous cell and melanoma), nervous system and endocrine glands and against myeloma and non-Hodgkin's lymphoma. The present results indicated that men who had had children with multiple women showed an excess of smoking- and alcohol consumption-related cancers. The decreased risks for colon cancer, non-Hodgkin's lymphoma and melanoma were possibly related to lifestyle factors connected with economic deprivation, less obesity and physical fitness. These ill-defined protected factors may be a challenge to epidemiological studies.
我们使用瑞典全国家庭癌症数据库来分析与多名女性育有子女的男性的癌症风险。癌症病例从1961年至1998年的瑞典癌症登记处检索获得。共涵盖了290万名男性和298,134例癌症病例。对于与两名、三名或更多名女性育有子女的男性，上消化道、肺癌、膀胱癌和食道癌的风险呈上升趋势。观察到结肠癌、皮肤癌（鳞状细胞癌和黑色素瘤）、神经系统和内分泌腺肿瘤以及骨髓瘤和非霍奇金淋巴瘤的风险呈下降趋势。目前的结果表明，与多名女性育有子女的男性患与吸烟和饮酒相关癌症的风险更高。结肠癌、非霍奇金淋巴瘤和黑色素瘤风险降低可能与经济贫困、肥胖程度较低和身体健康等生活方式因素有关。这些定义不明确的保护因素可能对流行病学研究构成挑战。
