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层层组装的指数增长来制备 pH 响应的分级纳米多孔聚合物膜及其优异的控制释放性能。

Exponentially growing layer-by-layer assembly to fabricate pH-responsive hierarchical nanoporous polymeric film and its superior controlled release performance.

机构信息

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.

出版信息

Chem Commun (Camb). 2010 Dec 28;46(48):9161-3. doi: 10.1039/c0cc03267k. Epub 2010 Nov 1.

DOI:10.1039/c0cc03267k
PMID:21042599
Abstract

A hierarchical nanoporous polymer film was fabricated through exponentially growing layer-by-layer assembly of weak polyelectrolytes without any template and post-treatment to greatly enhance loading capacity, release time and linear release range with pH-dependence for small molecules over the reported weak polyelectrolyte films, providing great potentials in controlled drug release applications.

摘要

通过无模板和后处理的弱聚电解质逐层组装的指数增长，制备了一种分级纳米多孔聚合物薄膜，极大地提高了小分子的载药量、释放时间和线性释放范围，具有 pH 依赖性，优于已报道的弱聚电解质薄膜，在控制药物释放应用中具有很大的潜力。

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