Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
J Hepatobiliary Pancreat Sci. 2011 Mar;18(2):263-7. doi: 10.1007/s00534-010-0340-y.
BACKGROUND/PURPOSE: It is important to determine the health-related quality of life of live donors in liver transplantation.
We reviewed 35 live liver donors and prospectively and longitudinally evaluated their health-related quality for 1.5 years post-surgery based on the Short Form-36 version 2 questionnaire. Scores of the donors stratified by the clinical data were analyzed. The study was approved by the University of Tokyo Institutional Review Board (No. 1533).
There was no donor mortality in the donor population studied. The percentage of major complications greater than Clavien's classification grade III was 8.6%. The physical component summary score decreased to 42.9 (p < 0.01) at 3 months, but recovered within 6 months after the operation. The mental component summary scores did not change during the observation period. The stratification study revealed that age and postoperative complications remained significant factors among the high physical component summary scores 3 months after the operation.
The findings from this survey suggest that liver harvesting does not decrease the donor's quality of life during the 1.5 years following the surgery.
背景/目的：确定肝移植中活体供者的健康相关生活质量很重要。
我们回顾了 35 例活体肝供者，并根据短期表单-36 版本 2 问卷，前瞻性和纵向地评估了他们术后 1.5 年的健康相关生活质量。对按临床数据分层的供者的评分进行了分析。该研究得到了东京大学机构审查委员会的批准（No. 1533）。
在所研究的供者群体中，没有供者死亡。大于 Clavien 分级 III 级的主要并发症的比例为 8.6%。术后 3 个月时，生理成分综合评分降至 42.9（p<0.01），但术后 6 个月内恢复。在观察期间，心理成分综合评分没有变化。分层研究表明，年龄和术后并发症仍然是术后 3 个月时高生理成分综合评分的显著因素。
本调查结果表明，在术后 1.5 年内，肝采集不会降低供者的生活质量。
