Division of Health Science, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Clin Transplant. 2019 Jun;33(6):e13584. doi: 10.1111/ctr.13584. Epub 2019 May 9.
This study examined the long-term quality of life (QOL) of living liver donors (LLDs) in Japan using both generic and LLD-specific instruments.
The sample comprised 374 LLDs from five university hospitals in Japan who underwent surgery more than a year previously. QOL was evaluated using the Short Form-36 health survey (SF-36) and LLD-QOL scale.
SF-36 results indicated that the overall long-term QOL of LLDs was significantly better than the Japanese standard. When comparing by donor factors, LLDs whose recipients were children scored higher for "satisfaction" than those whose recipients were adults on the LLD-QOL scale. LLDs with complications had lower QOL for "scars" and "burden" on the LLD-QOL scale but no differences in SF-36 scores. LLDs with longer hospital stay had lower physical QOL on SF-36 and lower QOL for "scars" and "after-effects" on the LLD-QOL scale. LLDs whose recipients have died showed lower mental QOL on SF-36 and lower "satisfaction" and greater "lack of understanding of donor health" on the LLD-QOL scale.
Our multicenter study clarified the long-term QOL of LLDs and suggested that donors' QOL was related to the donors' and recipients' ages, donor's complications and hospital stay length, and recipient's prognosis.
本研究使用通用和 LLD 特异性工具评估日本活体肝供者（LLD）的长期生活质量（QOL）。
该样本包括来自日本五所大学医院的 374 名 LLD，他们在一年多前接受了手术。使用短表 36 健康调查（SF-36）和 LLD-QOL 量表评估 QOL。
SF-36 结果表明，LLD 的总体长期 QOL 明显优于日本标准。按供者因素比较时，受体为儿童的 LLD 在 LLD-QOL 量表上的“满意度”评分高于受体为成人的 LLD。有并发症的 LLD 在 LLD-QOL 量表上的“疤痕”和“负担”的 QOL 较低，但 SF-36 评分无差异。住院时间较长的 LLD 在 SF-36 上的身体 QOL 较低，在 LLD-QOL 量表上的“疤痕”和“后遗症”的 QOL 较低。受体死亡的 LLD 在 SF-36 上的精神 QOL 较低，在 LLD-QOL 量表上的“满意度”较低，“对供体健康缺乏了解”的程度较大。
我们的多中心研究阐明了 LLD 的长期 QOL，并表明供者的 QOL 与供者和受体的年龄、供者的并发症和住院时间长短以及受体的预后有关。
