Department of Experimental Medicine, Division of Gerontology and Geriatrics, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium.
Diabetes Metab Res Rev. 2010 Nov;26(8):668-76. doi: 10.1002/dmrr.1144.
Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting. We investigated the association between metabolic syndrome and cognitive function in a population sample of middle-aged and older European men and whether any observed association could be explained by lifestyle or other confounding factors.
A total of 3369 men in the 40- to 79-year age group were recruited from population registers in eight centres for participation in the European Male Ageing Study. The subjects completed a questionnaire instrument and several cognitive function tests including the Rey-Osterrieth Complex Figure test, the Camden Topographical Recognition Memory test and the Digit Symbol Substitution Test. Metabolic syndrome data were assessed at an invited visit and metabolic syndrome was defined by the National Cholesterol Education Program's Adult Treatment Panel-III criteria. Associations between cognitive performance and metabolic syndrome were explored using linear regression.
Complete cognitive and metabolic syndrome data from 3152 subjects were included in the analysis, of whom 1007 (32%) fulfilled criteria for metabolic syndrome. After adjustment for putative health and lifestyle confounders, no significant associations were found between any of the cognitive function scores and metabolic syndrome or between cognitive performance and high-sensitivity C-reactive protein. Analysis of the individual metabolic syndrome factors, however, revealed an inverse association between the level of glucose and cognitive performance.
Metabolic syndrome was not associated with cognitive impairment in this population. Of the individual components of the syndrome, diabetes was associated with poorer performances in memory, executive functions and processing speed, associations that warrant further investigation.
代谢综合征被报道对认知功能有不良影响，尽管结果存在冲突。我们在中年和老年欧洲男性的人群样本中研究了代谢综合征与认知功能之间的关系，以及任何观察到的关联是否可以通过生活方式或其他混杂因素来解释。
共有 3369 名年龄在 40 至 79 岁的男性从八个中心的人口登记处招募，参加欧洲男性衰老研究。受试者完成了一份问卷工具和几项认知功能测试，包括 Rey-Osterrieth 复杂图形测试、Camden 拓扑识别记忆测试和数字符号替代测试。代谢综合征数据在受邀访问时进行评估，代谢综合征的定义采用国家胆固醇教育计划成人治疗专家组-III 标准。使用线性回归探索认知表现与代谢综合征之间的关系。
在纳入分析的 3152 名受试者中，有 3152 名完成了完整的认知和代谢综合征数据，其中 1007 名（32%）符合代谢综合征标准。在调整了潜在的健康和生活方式混杂因素后，认知功能评分与代谢综合征之间或认知表现与高敏 C 反应蛋白之间没有显著关联。然而，对代谢综合征各个因素的分析表明，血糖水平与认知表现呈负相关。
在该人群中，代谢综合征与认知障碍无关。在该综合征的各个组成部分中，糖尿病与记忆、执行功能和处理速度的表现较差有关，这些关联值得进一步研究。
