Basu Deepjoy, Sengupta Arunabha, Adhikari Debasish, Dam Amit, Anwar Tarique
Department of Otolaryngology, SSKM Hospital, Kolkata 700020.
J Indian Med Assoc. 2010 Mar;108(3):170, 175.
Granular cell tumours are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. It is not clear whether or not granular cell tumour is a true neoplasm, a developmental anomaly, or a trauma-induced proliferation. The basic cell of origin is now thought to be neural, although past reports frequently indicated an origin from striated muscle, or less frequently an origin from histiocytes, fibroblasts or pericytes. The tongue and the buccal mucosa are common intraoral sites. The other head and neck site likely to be involved is the larynx. The tumour generally occurs in middle or older aged adults. More than a third of all granular cell tumours occur on the lingual dorsum, usually as a sessile, painless, somewhat firm, immoveable nodule less than 1.5 cm in greatest diameter. Lesions often demonstrate a pallor or a yellowish discolouration and typically have a smooth surface. Histochemical and ultrastructural studies propose the origin of the lesion from Schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells. As most of the granular cell tumours are benign, surgical excision of the lesion is the treatment of choice.
颗粒细胞瘤是一种罕见的病变，尽管头颈部区域约占所有病变的50%。目前尚不清楚颗粒细胞瘤是真正的肿瘤、发育异常还是创伤性增殖。虽然过去的报告经常表明其起源于横纹肌，或较少起源于组织细胞、成纤维细胞或周细胞，但现在认为其基本起源细胞是神经源性的。舌和颊黏膜是常见的口腔内发病部位。头颈部其他可能受累的部位是喉。该肿瘤通常发生于中老年人。超过三分之一的颗粒细胞瘤发生于舌背，通常为无蒂、无痛、质地稍硬、不可移动的结节，最大直径小于1.5厘米。病变常表现为苍白或淡黄色，表面通常光滑。组织化学和超微结构研究提示该病变起源于施万细胞、横纹肌、间充质细胞、组织细胞和上皮细胞。由于大多数颗粒细胞瘤是良性的，手术切除病变是首选的治疗方法。
