Cobanoğlu Nazan, Ozcelik Uğur, Cetin Ilker, Yalçin Ebru, Doğru Deniz, Kiper Nural, Bakkaloğlu Ayşin
Unit of Pediatric Pulmonary Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2010 Jul-Aug;52(4):343-7.
We investigated the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in the serum and bronchoalveolar lavage fluid (BALF) of 21 cystic fibrosis (CF), 7 idiopathic bronchiectasis (IBR), and 11 control children and the relation between ANCA and any bacteria grown in BALF. Six of the CFs, but none of the IBRs or controls had positive serum cytoplasmic or perinuclear-ANCA (c-ANCA, p-ANCA). Serum autoantibodies against bactericidal/permeability increasing protein (BPI-ANCA) were positive in 2 CFs, 1 IBR and 1 control. While none of the CFs, IBRs or controls had positive BALF (c- or p-ANCA), 1 CF, 1 IBR and none of the controls had positive BALF BPI-ANCA. Pseudomonas aeruginosa was not grown in the specimens of any of the subjects. As the number of the patients in our study was very limited, further longitudinal and well-designed studies are necessary to show whether or not the presence of ANCA in serum or BALF relates to the presence of P. aeruginosa infection in the airways of CF and IBR patients.
我们调查了21例囊性纤维化（CF）、7例特发性支气管扩张（IBR）患儿以及11例对照儿童血清和支气管肺泡灌洗液（BALF）中抗中性粒细胞胞浆抗体（ANCA）的存在情况，以及ANCA与BALF中培养出的任何细菌之间的关系。6例CF患儿血清胞浆型或核周型ANCA（c-ANCA、p-ANCA）呈阳性，但IBR患儿和对照儿童均无阳性。2例CF患儿、1例IBR患儿和1例对照儿童血清中抗杀菌/通透性增加蛋白抗体（BPI-ANCA）呈阳性。虽然CF患儿、IBR患儿和对照儿童的BALF中（c-ANCA或p-ANCA）均无阳性，但1例CF患儿、1例IBR患儿的BALF中BPI-ANCA呈阳性，对照儿童均为阴性。所有受试者的标本中均未培养出铜绿假单胞菌。由于我们研究中的患者数量非常有限，因此有必要进行进一步的纵向和精心设计的研究，以确定血清或BALF中ANCA的存在是否与CF和IBR患者气道中铜绿假单胞菌感染的存在有关。
