Iwuji Kenneth, Larumbe-Zabala Eneko, Bijlani Sharan, Nugent Kenneth, Kanu Adaobi, Manning Erena, Solis Ximena
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
Clinical Research Institute, Texas Tech University Health Sciences Center, Lubbock, Texas.
Pediatr Allergy Immunol Pulmonol. 2019 Jun 1;32(2):45-51. doi: 10.1089/ped.2018.0970. Epub 2019 Jun 17.
There have been varying reports on the prevalence of antineutrophil cytoplasmic antibodies with bactericidal/permeability-increasing protein (BPI-ANCA) specificity in cystic fibrosis (CF) patients. These autoantibodies are believed to develop in response to infection and colonization, especially with . The aim of this review was to estimate the overall prevalence of BPI-ANCA in CF patients. We searched PubMed, Scopus, and Embase databases for studies reporting the prevalence of BPI-ANCA in CF patients. We also searched the and our institution's library for relevant studies on BPI-ANCA. We calculated the proportion with a 95% confidence interval (CI) to assess the prevalence of BPI-ANCA in the individual studies and then pooled the results using a random effects model. Publication bias was assessed using graphical and statistical methods. Finally, we assessed statistical heterogeneity using the test. Our search yielded 12 eligible studies published between 1996 and 2015. The prevalence of BPI-ANCA in patients with CF varied from 17.9% to 83% with a pooled prevalence of 49.45% (95% CI 35.53-63.42). No evidence of bias was found. However, there was evidence of statistically significant variation in the prevalence estimate due to heterogeneity ( = 93.4%, < 0.01). Given the highly varying prevalence of BPI-ANCA in patients with CF, more well-designed prospective clinical studies are needed to determine its true prevalence and clinical relevance.
关于囊性纤维化（CF）患者中具有杀菌/通透性增加蛋白（BPI-ANCA）特异性的抗中性粒细胞胞浆抗体的患病率，已有不同的报道。这些自身抗体被认为是对感染和定植的反应而产生的，尤其是对……。本综述的目的是估计CF患者中BPI-ANCA的总体患病率。我们在PubMed、Scopus和Embase数据库中搜索了报告CF患者中BPI-ANCA患病率的研究。我们还在……和我们机构的图书馆中搜索了关于BPI-ANCA的相关研究。我们计算了95%置信区间（CI）的比例，以评估个体研究中BPI-ANCA的患病率，然后使用随机效应模型汇总结果。使用图形和统计方法评估发表偏倚。最后，我们使用……检验评估统计异质性。我们检索到1996年至2015年间发表的12项符合条件的研究。CF患者中BPI-ANCA的患病率从17.9%到83%不等，合并患病率为49.45%（95%CI 35.53 - 63.42））。未发现偏倚证据。然而有证据表明，由于异质性，患病率估计存在统计学显著差异（……=93.4%，……<0.01））。鉴于CF患者中BPI-ANCA患病率差异很大 需要更多设计良好的前瞻性临床研究来确定其真实患病率和临床相关性。
