贯叶金丝桃中的环木菠萝烷型二萜、酰基间苯三酚和二氢黄酮。

Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense.

机构信息

School of Pharmacy, Fudan University, Shanghai, People's Republic of China.

出版信息

J Nat Prod. 2010 Nov 29;73(11):1815-20. doi: 10.1021/np1004483. Epub 2010 Nov 2.

Abstract

Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 μg/mL (8.4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM).

摘要

从贯叶连翘中分离得到了两个新的木脂素，即 hyperiones A（1）和 B（2），三个新的酰基间苯三酚，即 aspidinol C（3）和 hyperaspidinols A（5）和 B（6），已知化合物 aspidinol D（4），以及对称二聚体 xanthone hyperidixanthone（7）。通过光谱分析确定了它们的结构。在使用多药耐药（MDR）菌株进行的抗菌测定中，化合物 3 和 4 对过度表达 NorA 外排蛋白的 MDR 金黄色葡萄球菌 SA-1199B 菌株表现出有希望的活性，最小抑菌浓度（MIC）分别为 2 μg/mL（8.4 μM）和 4 μg/mL（16.8 μM）。阳性对照抗生素诺氟沙星的活性在 MIC 32 μg/mL（100 μM）。