Singh Medha, Stark Paul C, Palmer Carole A, Gilbard Jeffrey P, Papas Athena S
Division of Oral Medicine and Dental Research, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
Spec Care Dentist. 2010 Nov-Dec;30(6):225-9. doi: 10.1111/j.1754-4505.2010.00158.x. Epub 2010 Oct 19.
To determine whether omega-3 (n-3) increases saliva production in patients with Sjögren's syndrome, 61 patients with Sjögren's received either wheat germ oil (n = 23) or n-3 supplement (TheraTears Nutrition®) (n = 38) in a prospective, randomized, double-masked trial. The outcomes assessed were salivary secretion and markers for oral inflammation. The differences between the n-3 group and wheat germ oil group were not statistically significant for either unstimulated (US) or stimulated (SS) salivary secretion (p= 0.38 and p= 0.346, respectively) nor for the number of sites with probing depth (PD) ≥ 4 mm (p= 0.834). In this pilot study, supplementation with n-3 was not found to be significantly better than wheat germ oil in stimulating saliva production in patients with Sjögren's syndrome.
为了确定ω-3（n-3）是否能增加干燥综合征患者的唾液分泌，61例干燥综合征患者参与了一项前瞻性、随机、双盲试验，其中23例接受小麦胚芽油治疗，38例接受n-3补充剂（TheraTears Nutrition®）治疗。评估的结果包括唾液分泌和口腔炎症标志物。n-3组和小麦胚芽油组在非刺激性（US）或刺激性（SS）唾液分泌方面的差异均无统计学意义（分别为p = 0.38和p = 0.346），在探诊深度（PD）≥4mm的部位数量上也无统计学意义（p = 0.834）。在这项初步研究中，未发现补充n-3在刺激干燥综合征患者唾液分泌方面显著优于小麦胚芽油。
