Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Lipids Health Dis. 2010 Nov 2;9:126. doi: 10.1186/1476-511X-9-126.
Conjugated linoleic acids (CLA) are a group of positional and geometric isomers of linoleic acid with proven beneficial influence on health. They show e.g. anticarcinogenic, antiobesity, and antiatherogenic effect. Milk, dairy products and meat of poligastric animals are their most valuable dietary sources, with cis-9, trans-11 CLA (RA--rumenic acid) being the predominant isomer. Dietary supplements with CLA became very popular, mainly among the overweight and bodybuilders.The aim of this study was to examine the influence of the food supplements with conjugated linoleic acid on carcinogenesis in female Sprague-Dawley rats and evaluation of CLA and other fatty acids distribution in their bodies.Animals were divided into four groups depending on the diet supplementation (oil or Bio-C.L.A. (Pharma Nord Denmark) given intragastrically) and presence or absence of carcinogenic agent (7,12-dimethylbenz[a]antharcene). Animals were decapitated at 21st week of experiment and serum and microsomes were extracted.
The mammary tumours (adenocarcinoma) occurred in groups treated with DMBA. Diet enriched with CLA decreased the cancer morbidity (67% in Bio-C.L.A. compared to 88% in oil) and delayed the cancer induction (p = 0.0018). There were no differences in body and organs weight.The supplement used in the study was a mixture of several fatty acids with the greatest proportion of CLA isomers: trans-10, cis-12 (33%) and cis-9, trans-11 (31%). Both of them were present in tissues but the content of rumenic acid was greater. Dietary supplementation had also significant impact on other fatty acids content, both in serum and in microsomes.
共轭亚油酸（CLA）是一组亚油酸的位置和几何异构体，已被证明对健康有益。它们具有抗癌、抗肥胖和抗动脉粥样硬化作用。牛奶、乳制品和多胃动物的肉是其最有价值的饮食来源，其中顺式-9，反式-11 CLA（RA-蓖麻酸）是主要的异构体。CLA 的膳食补充剂非常受欢迎，主要是在超重和健美运动员中。本研究旨在研究共轭亚油酸的膳食补充剂对雌性 Sprague-Dawley 大鼠致癌作用的影响，并评价 CLA 和其他脂肪酸在其体内的分布。
动物根据饮食补充（油或 Bio-C.L.A.（丹麦 Pharma Nord）灌胃）和致癌剂（7,12-二甲基苯并[a]蒽）的存在与否分为四组。实验第 21 周时，动物断头并提取血清和微粒体。
用 DMBA 处理的组发生乳腺肿瘤（腺癌）。CLA 丰富的饮食降低了癌症发病率（Bio-C.L.A.组为 67%，油组为 88%）并延迟了癌症诱导（p = 0.0018）。体重和器官重量无差异。研究中使用的补充剂是几种脂肪酸的混合物，其中 CLA 异构体的比例最大：反式-10，顺式-12（33%）和顺式-9，反式-11（31%）。两者都存在于组织中，但蓖麻酸的含量更高。饮食补充剂对血清和微粒体中其他脂肪酸的含量也有显著影响。
