Białek Agnieszka, Jelińska Małgorzata, Białek Małgorzata, Lepionka Tomasz, Czerwonka Małgorzata, Czauderna Marian
Department of Animal Improvement and Nutrigenomics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postępu 36A Jastrzębiec, 05-552 Magdalenka, Poland.
Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Antioxidants (Basel). 2020 Mar 17;9(3):243. doi: 10.3390/antiox9030243.
The aim of this study was to present overall lipid profile of organisms with ongoing neoplastic process and applied diet supplementation with pomegranate seed oil (PSO) and bitter melon extract (BME). The following were quantified in serum and cancerous tissues of rats suffering from mammary tumours: fatty acids, conjugated fatty acids and sterols, their oxidised metabolites (malondialdehyde and oxysterols) and lipoxygenase (LOX) metabolites of polyunsaturated fatty acids. The obtained results indicate that abnormalities in lipid metabolism accompany neoplastic process. These differences concern all classes of lipids and most pathways of their transformation, with the special emphasis on lipid peroxidation and LOX-mediated metabolism. Cancer process appears to be so detrimental that it may conceal positive influence of dietary modifications. The lack of anticarcinogenic properties of PSO and BME in this model may be due to their antioxidant properties or elevated levels of conjugated linoleic acids (CLA), which change CLA isomer activity from anti- to pro-tumorigenic. As CLA are the product of conjugated linolenic acids (CLnA) endogenous metabolism, high CLA levels may be explained by applied diet enrichment.
本研究的目的是呈现正在发生肿瘤过程的生物体的整体脂质概况，并应用石榴籽油（PSO）和苦瓜提取物（BME）进行饮食补充。对患有乳腺肿瘤的大鼠的血清和癌组织中的以下物质进行了定量分析：脂肪酸、共轭脂肪酸和甾醇、它们的氧化代谢产物（丙二醛和氧化甾醇）以及多不饱和脂肪酸的脂氧合酶（LOX）代谢产物。所得结果表明，脂质代谢异常伴随着肿瘤过程。这些差异涉及所有类别的脂质及其大多数转化途径，特别强调脂质过氧化和LOX介导的代谢。癌症过程似乎具有如此大的危害性，以至于可能掩盖饮食调整的积极影响。在该模型中，PSO和BME缺乏抗癌特性可能是由于它们的抗氧化特性或共轭亚油酸（CLA）水平升高，这会将CLA异构体的活性从抗癌转变为促肿瘤。由于CLA是共轭亚麻酸（CLnA）内源性代谢的产物，高CLA水平可能是由于所应用的饮食富集所致。
