Unit of Infectious Disease, Microbiology, and Preventive Medicine, Institute of Biomedicine of Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, 41013 Sevilla, Spain.
Vaccine. 2010 Dec 10;29(1):1-5. doi: 10.1016/j.vaccine.2010.10.052. Epub 2010 Nov 18.
The treatment of infections caused by Acinetobacter baumannii has become increasingly complicated due to the emergence of highly resistant strains. In the present study we demonstrate that immunization with an inactivated whole cell vaccine elicits a robust antibody response that provides protection against challenge with multiple A. baumannii strains in a murine model of disseminated sepsis. In addition, we show that passive immunization with serum raised against inactivated cells protects mice from subsequent infection. These results demonstrate that active and passive immunization using an inactivated whole cell vaccine may be an effective approach for preventing infection by A. baumannii.
由于高度耐药菌株的出现，鲍曼不动杆菌感染的治疗变得越来越复杂。在本研究中，我们证明了用灭活全细胞疫苗免疫可引起强烈的抗体反应，在播散性败血症的小鼠模型中提供针对多种鲍曼不动杆菌菌株的保护。此外，我们还表明，用针对灭活细胞的血清进行被动免疫可保护小鼠免受随后的感染。这些结果表明，使用灭活全细胞疫苗进行主动和被动免疫可能是预防鲍曼不动杆菌感染的有效方法。
