University of California San Francisco, CA 94110, USA.
Arch Phys Med Rehabil. 2010 Nov;91(11):1667-72. doi: 10.1016/j.apmr.2010.05.018.
Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI.
基因组学、蛋白质组学和生物技术的最新进展为转化研究和个性化医学提供了前所未有的机会。人类生物样本和生物流体是一种重要的资源，可以从中生成分子数据，以检测和分类损伤，并确定分子机制和治疗靶点。迄今为止，在创伤性脑损伤 (TBI) 研究中，生物样本和生物流体的采集、存储和处理存在相当大的变异性。为了充分发挥这一重要资源的潜力，需要标准化和采用最佳实践指南，以确保这些样本的质量和一致性。生物样本和生物标志物工作组的目的是为 TBI 研究提供核心数据元素的建议，并制定最佳实践指南，以标准化这些样本的质量和可及性。通过与焦点小组的互动以及参与 2009 年 3 月在华盛顿特区举行的创伤性脑损伤和心理健康数据收集标准化机构间研讨会的利益相关者的投入，制定了共识建议。随着这些标准和最佳实践的采用，未来的研究人员将能够在降低成本和工作量的情况下，从多个研究中获取数据，并加速 TBI 中基因组学、蛋白质组学和代谢组学研究的进展。
