精确调控基因表达：表观基因组。
Fine tuning gene expression: the epigenome.
机构信息
Department of Pediatrics, Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Semin Nephrol. 2010 Sep;30(5):468-76. doi: 10.1016/j.semnephrol.2010.07.004.
Abstract
An epigenetic trait is a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence. Epigenetic modifications such as DNA methylation, together with covalent modification of histones, are thought to alter chromatin density and accessibility of the DNA to cellular machinery, thereby modulating the transcriptional potential of the underlying DNA sequence. As environmental changes influence epigenetic marks, epigenetics provides an added layer of variation that might mediate the relationship between genotype and internal and external environmental factors. Integration of our knowledge in genetics, epigenomics, and genomics with the use of systems biology tools may present investigators with new, powerful tools to study many complex human diseases such as kidney disease.
摘要
表观遗传特征是一种稳定遗传的表型，源于染色体的变化而不改变 DNA 序列。表观遗传修饰，如 DNA 甲基化，以及组蛋白的共价修饰，被认为可以改变染色质密度和 DNA 对细胞机制的可及性，从而调节潜在 DNA 序列的转录潜能。由于环境变化会影响表观遗传标记，因此表观遗传学提供了一个额外的变异层，可能介导基因型与内部和外部环境因素之间的关系。将我们在遗传学、表观基因组学和基因组学方面的知识与系统生物学工具的使用相结合，可能为研究人员提供新的、强大的工具，以研究许多复杂的人类疾病，如肾脏疾病。
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本文引用的文献
1
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Nature. 2009 Nov 19;462(7271):315-22. doi: 10.1038/nature08514. Epub 2009 Oct 14.
2
X inactivation and disease.X 染色体失活与疾病。
Semin Cell Dev Biol. 2010 Apr;21(2):194-200. doi: 10.1016/j.semcdb.2009.09.017. Epub 2009 Oct 6.
3
Uremic memory: the role of acute kidney injury in long-term outcomes.尿毒症记忆：急性肾损伤在长期预后中的作用。
Kidney Int. 2009 Oct;76(8):813-4. doi: 10.1038/ki.2009.314.
4
Mouse models of diabetic nephropathy.糖尿病肾病的小鼠模型。
J Am Soc Nephrol. 2009 Dec;20(12):2503-12. doi: 10.1681/ASN.2009070721. Epub 2009 Sep 3.
5
Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease.需要透析的急性肾衰竭会增加进展为慢性肾病的风险。
Kidney Int. 2009 Oct;76(8):893-9. doi: 10.1038/ki.2009.289. Epub 2009 Jul 29.
6
X inactivation and the complexities of silencing a sex chromosome.X染色体失活与沉默性染色体的复杂性。
Curr Opin Cell Biol. 2009 Jun;21(3):359-66. doi: 10.1016/j.ceb.2009.04.012. Epub 2009 May 26.
7
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Nucleic Acids Res. 2009 Jul;37(12):3829-39. doi: 10.1093/nar/gkp260. Epub 2009 Apr 22.
8
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PLoS One. 2009;4(3):e4802. doi: 10.1371/journal.pone.0004802. Epub 2009 Mar 11.
9
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.高血糖会诱导组蛋白甲基化酶和去甲基化酶的动态协同作用，这些酶与赖氨酸尾巴上共存的基因激活表观遗传标记相关。
Diabetes. 2009 May;58(5):1229-36. doi: 10.2337/db08-1666. Epub 2009 Feb 10.
10
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Int J Biochem Cell Biol. 2009 Jan;41(1):87-95. doi: 10.1016/j.biocel.2008.09.005. Epub 2008 Sep 13.
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