Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):562-70. doi: 10.1016/j.colsurfb.2010.10.018. Epub 2010 Oct 15.
Nanometre hydroxyapatite (nHA) coated metallic materials have been successfully used for bone tissue implantation for several decades now due to its sound biological and mechanical properties. The microstructure and surface topography of the implant material are well-known to play a crucial role in influencing cellular responses to implants and bone tissue regeneration ultimately. Recently, a novel jet-based patterning technique, template-assisted electrohydrodynamic atomisation (TAEA) spraying, has been devised to prepare depositions with defined surface topography for guiding the cellular response. In this study, an improvement investigation of this patterning process was carried out to precisely control the nHA surface structure in terms of geographies and dimensions via an angular needle jetting during the patterning process. More importantly, the mechanism of such improvement of the TAEA patterning technique was also discussed and uncovered. A range of diverse nHA surface structures with high-resolution was therefore achieved, which paves the way for the research of the new generation implant materials with defined cellular response.
纳米羟基磷灰石（nHA）涂层金属材料由于其良好的生物和机械性能，现已成功用于骨组织植入数十年。植入材料的微观结构和表面形貌已知对影响细胞对植入物的反应和骨组织再生起着至关重要的作用。最近，一种新颖的基于喷射的图案化技术，模板辅助静电喷雾（TAEA）喷射，已被设计用于制备具有定义表面形貌的沉积物，以引导细胞反应。在这项研究中，通过在图案化过程中进行角度针喷射，对该图案化过程进行了改进研究，以精确控制 nHA 表面结构的地理和尺寸。更重要的是，还讨论并揭示了 TAEA 图案化技术改进的机制。因此，实现了一系列具有高分辨率的不同 nHA 表面结构，为具有定义细胞反应的新一代植入材料的研究铺平了道路。
