Department of Mechanical Engineering, University College London, Torrington's Place, London WC1E 7JE, UK.
J R Soc Interface. 2010 Jan 6;7(42):189-97. doi: 10.1098/rsif.2009.0101. Epub 2009 Jun 3.
Surface topography is well known to play a crucial role in influencing cellular responses to an implant material and is therefore important in bone tissue regeneration. A novel jet-based patterning technique, template-assisted electrohydrodynamic atomization spraying, was recently devised to control precisely the surface structure as well as its dimensions. In the present study, a detailed investigation of this patterning process was carried out. A range of nano-hydroxyapatite (nHA) line-shaped patterns <20 microm in width were successfully deposited on a commercially pure Ti surface by controlling the flow of an nHA suspension in an electric field. In vitro studies showed that the nHA patterns generated are capable of regulating the human osteoblast cell attachment and orientation.
表面形貌众所周知对细胞对植入材料的反应起着至关重要的作用，因此在骨组织再生中很重要。最近设计了一种新颖的基于射流的图案化技术，模板辅助的电动力学雾化喷涂，以精确控制表面结构及其尺寸。在本研究中，对该图案化过程进行了详细的研究。通过控制 nHA 悬浮液在电场中的流动，成功地在商业纯 Ti 表面上沉积了一系列宽度小于 20 微米的纳米羟基磷灰石（nHA）线状图案。体外研究表明，生成的 nHA 图案能够调节人成骨细胞的附着和定向。
