Bánóczy J, Ritlop B, Solymosi G, Gombik A, Adatia A
Department of Conservative Dentistry, Semmelweis Medical University, Budapest, Hungary.
Acta Physiol Hung. 1990;76(4):341-6.
The aim of the study was to get further experimental data on the anticariogenic effect of sodium fluoride (NaF) when administered in milk or water. Thirty six weanling Osborne-Mendel rats were divided into two experimental groups (A, B) of 12 rats each and two control groups (C, D) of six rats each. During the experimental period of four weeks all animals were superinfected with Strep. mutans (NCTC 10449), kept in an automatic feeding machine and given a cariogenic diet (MIT 301). Group A received sodium fluoride (NaF) in water (15 ppm) and group B in ultra high temperature treated milk. Groups C and D respectively received plain milk and distilled water. Group A did not show significantly lower caries reduction compared with the control groups. Group B had significantly the lowest caries scores compared with all other groups. Scores in group C (plain milk) were lower than those in groups D (plain water). The results suggest that the anticariogenic effect of NaF is more pronounced when the vehicle is milk instead of water.
该研究的目的是获取关于氟化钠（NaF）在牛奶或水中给药时防龋效果的更多实验数据。36只断乳的奥斯本-孟德尔大鼠被分为两个实验组（A组、B组），每组12只，以及两个对照组（C组、D组），每组6只。在为期四周的实验期内，所有动物均被变形链球菌（NCTC 10449）超级感染，饲养在自动喂食机中，并给予致龋饮食（MIT 301）。A组在水中接受氟化钠（NaF）（15 ppm），B组在超高温处理的牛奶中接受氟化钠。C组和D组分别接受纯牛奶和蒸馏水。与对照组相比，A组的龋齿减少量没有显著降低。与所有其他组相比，B组的龋齿得分显著最低。C组（纯牛奶）的得分低于D组（纯水）。结果表明，当载体是牛奶而非水时，NaF的防龋效果更显著。
