Liu Hui, Liu Wei, Liao Yifang, Cheng Long, Liu Qian, Ren Xiang, Shi Lisong, Tu Xin, Wang Qing Kenneth, Guo An-Yuan
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China.
Nucleic Acids Res. 2011 Jan;39(Database issue):D991-6. doi: 10.1093/nar/gkq1106. Epub 2010 Nov 2.
Coronary artery disease (CAD) is a complex, multifactorial disease and a leading cause of mortality world wide. Over the past decades, great efforts have been made to elucidate the underlying genetic basis of CAD and massive data have been accumulated. To integrate these data together and to provide a useful resource for researchers, we developed the CADgene, a comprehensive database for CAD genes. We manually extracted CAD-related evidence for more than 300 candidate genes for CAD from over 1300 publications of genetic studies. We classified these candidate genes into 12 functional categories based on their roles in CAD. For each gene, we extracted detailed information from related studies (e.g. the size of case-control, population, SNP, odds ratio, P-value, etc.) and made useful annotations, which include general gene information, Gene Ontology annotations, KEGG pathways, protein-protein interactions and others. Besides the statistical number of studies for each gene, CADgene also provides tools to search and show the most frequently studied candidate genes. In addition, CADgene provides cumulative data from 11 publications of CAD-related genome-wide association studies. CADgene has a user-friendly web interface with multiple browse and search functions. It is freely available at http://www.bioguo.org/CADgene/.
冠状动脉疾病（CAD）是一种复杂的多因素疾病，也是全球范围内主要的死亡原因。在过去几十年里，人们为阐明CAD潜在的遗传基础付出了巨大努力，并积累了大量数据。为了整合这些数据并为研究人员提供有用的资源，我们开发了CADgene，这是一个关于CAD基因的综合数据库。我们从1300多篇遗传学研究出版物中手动提取了300多个CAD候选基因的相关证据。我们根据这些候选基因在CAD中的作用将它们分为12个功能类别。对于每个基因，我们从相关研究中提取详细信息（如病例对照、人群、单核苷酸多态性、优势比、P值等的规模）并进行有用的注释，包括一般基因信息、基因本体注释、KEGG通路、蛋白质-蛋白质相互作用等。除了每个基因的研究统计数量外，CADgene还提供搜索和展示研究最频繁的候选基因的工具。此外，CADgene提供了来自11篇CAD相关全基因组关联研究出版物的累积数据。CADgene有一个用户友好的网络界面，具有多种浏览和搜索功能。可在http://www.bioguo.org/CADgene/免费获取。
