上呼吸消化道肉瘤样癌：一项免疫组织化学分析显示8例患者中有一部分存在潜伏性EB病毒。
Sarcomatoid carcinoma of the upper aerodigestive tract: an immunohistochemical analysis demonstrating latent Epstein-Barr virus in a subset of eight cases.
作者信息
Etit Demet, Altinel Deniz, Bayol Umit, Tan Ayca, Cumurcu Suheyla
机构信息
Department of Pathology, Tepecik Research and Training Hospital, Izmir, Turkey.
出版信息
Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):750-6. doi: 10.4103/0377-4929.70969.
BACKGROUND
Sarcomatoid or spindle cell carcinomas are rare malignancies which are considered as a poorly differentiated variant of squamous cell carcinoma. Epstein-Barr virus (EBV) is associated with a wide variety of malignancies.
MATERIALS AND METHODS
We examined the expression of EBV latent membrane protein-1 (LMP-1) and EBV EBNA-2 as well as the immunohistochemical profile of AE-1/AE-3, vimentin, desmin, CK 5-6, smooth muscle actin (SMA), p63, S-100, p53 and CD-117 with the clinicopathological correlation of eight patients of sarcomatoid carcinoma (SC) in the upper aerodigestive tract.
RESULTS
Four cases showed EBV LMP-1 positivity (50%) and there was no EBV EBNA-2 positivity. However, the EBV LMP-1 results of our series could be considered only as a coincidental finding in the SCs of the upper aerodigestive tract.
CONCLUSIONS
This finding supports the idea that further studies based on larger series might be helpful enlighting the role played by EBV in carcinogenesis of SC.
背景
肉瘤样或梭形细胞癌是罕见的恶性肿瘤，被认为是鳞状细胞癌的一种低分化变体。爱泼斯坦-巴尔病毒（EBV）与多种恶性肿瘤相关。
材料与方法
我们检测了8例上呼吸道消化道肉瘤样癌（SC）患者的EBV潜伏膜蛋白-1（LMP-1）和EBV EBNA-2的表达，以及AE-1/AE-3、波形蛋白、结蛋白、细胞角蛋白5-6、平滑肌肌动蛋白（SMA）、p63、S-100、p53和CD-117的免疫组化特征，并分析其与临床病理的相关性。
结果
4例显示EBV LMP-1阳性（50%），无EBV EBNA-2阳性。然而，我们系列研究中EBV LMP-1的结果仅可被视为上呼吸道消化道SC中的一个偶然发现。
结论
这一发现支持这样一种观点，即基于更大样本量的进一步研究可能有助于阐明EBV在上呼吸道消化道SC致癌过程中所起的作用。
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