O'Cuinn G, O'Connor B, Elmore M
Department of Life Sciences, Regional Technical College, Galway, Ireland.
J Neurochem. 1990 Jan;54(1):1-13. doi: 10.1111/j.1471-4159.1990.tb13276.x.
In this article, the enzymes of brain and associated tissues that can degrade thyrotropin-releasing hormone (TRH) and luteinising hormone-releasing hormone (LH-RH) are reviewed. As both TRH and LH-RH are considered to act as neurotransmitters or neuromodulators in the CNS, attention is paid to the subcellular location of the enzymes described and how their topographies and substrate specificities fit them to playing roles as inactivating agents for TRH and LH-RH or as regulators of intracellular concentrations of TRH and LH-RH. Consideration is also given to enzymes involved in biotransformation of TRH to secondary metabolites that exhibit biological activity and to enzymes involved in the metabolism of secondary metabolites.
本文对可降解促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LH-RH）的脑及相关组织中的酶进行了综述。由于TRH和LH-RH在中枢神经系统中均被视为神经递质或神经调节剂，因此本文关注了所描述酶的亚细胞定位，以及它们的拓扑结构和底物特异性如何使其适合作为TRH和LH-RH的失活剂或作为TRH和LH-RH细胞内浓度的调节剂发挥作用。本文还考虑了参与将TRH生物转化为具有生物活性的次级代谢产物的酶，以及参与次级代谢产物代谢的酶。
