活细胞中的 RNA 折叠。
RNA folding in living cells.
机构信息
Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.
出版信息
RNA Biol. 2010 Nov-Dec;7(6):634-41. doi: 10.4161/rna.7.6.13554. Epub 2010 Nov 1.
Abstract
RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the rules governing intracellular RNA structure formation is still in its infancy. The cellular environment hosts a great diversity of factors that potentially influence RNA folding in vivo. For example, the nature of transcription and translation is known to shape the folding landscape of RNA molecules. Trans-acting factors such as proteins, RNAs and metabolites, among others, are also able to modulate the structure and thus the fate of an RNA. Here we summarize the ongoing efforts to uncover how RNA folds in living cells.
摘要
RNA 折叠是 RNA 功能的最基本过程。尽管在理解体外驱动 RNA 折叠的力方面已经取得了重大进展，但探索控制细胞内 RNA 结构形成的规则仍处于起步阶段。细胞环境中存在着多种多样的因素，这些因素可能会影响体内 RNA 的折叠。例如，转录和翻译的性质被认为会影响 RNA 分子的折叠景观。反式作用因子，如蛋白质、RNA 和代谢物等，也能够调节 RNA 的结构，从而影响其命运。在这里，我们总结了目前为揭示 RNA 在活细胞中如何折叠而做出的努力。
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