Department of Chemistry and Biophysics, The University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.
Nature. 2012 Feb 15;482(7385):322-30. doi: 10.1038/nature10885.
Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. The mechanisms by which cellular processes harness the intrinsic dynamic behaviour of RNA and use it within functionally productive pathways are complex. The versatile functions and ease by which it is integrated into a wide variety of genetic circuits and biochemical pathways suggests there is a general and fundamental role for RNA dynamics in cellular processes.
构象变化的编码和非编码 rna 形成的基础上的遗传调控元素,提供了一个重要的来源的复杂性,这推动了许多生命的基本过程。尽管 RNA 的结构具有高度的灵活性,RNA 的潜在动力学是稳健的,并且仅限于在少数构象之间的转变,保留有利的碱基配对和堆积相互作用。细胞过程利用 RNA 的固有动力学特性并在功能上有生产性的途径中使用它的机制是复杂的。多功能的功能和它被集成到各种各样的遗传电路和生化途径的简便性表明,RNA 动力学在细胞过程中具有普遍而基本的作用。
