Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, USA.
Cornea. 2011 Mar;30(3):351-3. doi: 10.1097/ICO.0b013e3181e9af33.
The purposes of this study are to report the first case of parotid gland adenoid cystic carcinoma (ACC) metastatic to the iris and ciliary body and suggest a successful treatment option.
A 64-year-old white man presented with a diffuse multilobulated amelanotic mass involving the peripheral iris and anterior chamber angle. Fine needle aspiration with a 27-gauge needle was performed, disclosing epithelial cells with positive staining for AE1/AE3 and morphologic features consistent with metastatic parotid gland ACC. Treatment with I plaque radiotherapy (40 Gy to the apex) was provided.
Five months later, the tumor remained regressed.
The systemic prognosis of salivary gland ACC is poor, with frequent local recurrences and late distance metastases. Even though uncommon, ocular metastases should be considered, and plaque radiotherapy may be useful to treat these patients.
本研究旨在报告首例腮腺腺样囊性癌（ACC）转移至虹膜和睫状体的病例，并提出一种成功的治疗选择。
一名 64 岁白人男性因累及周边虹膜和前房角的弥漫性多叶性无黑色素瘤肿块就诊。用 27 号针进行细针抽吸，显示出具有 AE1/AE3 阳性染色的上皮细胞，形态特征符合腮腺腺样囊性癌转移。给予 I 型放射性粒子敷贴治疗（顶点 40 Gy）。
5 个月后，肿瘤仍处于消退状态。
唾液腺 ACC 的全身预后较差，常发生局部复发和晚期远处转移。即使不常见，也应考虑眼部转移，并可能有用放射性粒子敷贴治疗这些患者。
