Khatam-al-Anbia Eye Hospital, Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Khorasan, Iran.
Cornea. 2011 Feb;30(2):117-20. doi: 10.1097/ICO.0b013e3181d5d920.
To evaluate the clinical results of a mechanical keratectomy with mitomycin C (MMC) and extended wear contact lens (EWCL) for the treatment of corneal haze after photorefractive keratectomy (PRK) of high myopia.
Eye Research Center, Khatam-al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Iran.
: In a retrospective interventional case series, we enrolled 15 eyes of 9 patients who previously underwent PRK for high myopia and developed corneal haze and regression. Mechanical removal of corneal haze was done by using a surgical blade number 15. Then, MMC (0.02%) was used for 2 minutes. An EWCL was applied for 1 month. The main outcome measures were uncorrected visual acuity, best-corrected visual acuity, spherical equivalent (SE), and corneal haze grade. All patients were followed for a minimum of 6 months.
The mean age of the patients was 25.66 ± 7.03 years; 7 patients were men and 2 patients were women. The mean best-corrected visual acuity before superficial keratectomy was 20/80 (range, 20/200-20/50) and improved to 20/20 after treatment (P < 0.05). Thirteen eyes (86.6%) achieved an uncorrected visual acuity of at least 20/40. The mean preoperative SE was 3.91 ± 1.30, and the mean final postoperative SE was -0.85 ± 1.19 (P < 0.05). Eight eyes (53%) were within 1 diopter of emmetropia. Corneal haze in all patients declined to a trace haze or complete clearness. No recurrence occurred during the mean follow-up time of 12 months.
Superficial keratectomy with MMC and EWCLs is effective in reducing persistent and refractory corneal haze after PRK.
评估机械性角膜切除术联合丝裂霉素 C（MMC）和延长佩戴接触镜（EWCL）治疗高度近视 PRK 术后角膜混浊和回退的临床效果。
伊朗马什哈德医科大学哈塔姆安比亚眼科医院眼研究中心。
回顾性病例系列研究，纳入 9 例（15 只眼）患者，这些患者先前因高度近视接受 PRK 治疗，术后出现角膜混浊和回退。采用手术刀片 15 号进行角膜混浊物机械清除，然后用 MMC（0.02%）作用 2 分钟。应用 EWCL 治疗 1 个月。主要观察指标为未矫正视力、最佳矫正视力、等效球镜（SE）和角膜混浊分级。所有患者均至少随访 6 个月。
患者的平均年龄为 25.66±7.03 岁；7 例为男性，2 例为女性。行浅层角膜切削术前平均最佳矫正视力为 20/80（20/200~20/50），术后提高至 20/20（P<0.05）。13 只眼（86.6%）获得至少 20/40 的未矫正视力。术前 SE 平均为 3.91±1.30，术后平均最终 SE 为-0.85±1.19（P<0.05）。8 只眼（53%）屈光度在 1 个屈光度以内。所有患者的角膜混浊均减轻至痕迹混浊或完全清晰。平均 12 个月随访期间无复发。
PRK 术后应用 MMC 和 EWCL 行浅层角膜切削术可有效减轻持续性和难治性角膜混浊。
