Hecht F, Ramesh K H, Lockwood D H
Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Cancer Genet Cytogenet. 1990 Jan;44(1):37-45. doi: 10.1016/0165-4608(90)90195-g.
This is a guide to 107 fragile sites, all those considered at the most recent International Workshop on Human Gene Mapping, HGM 9.5, held in 1988. The chromosome band locations of all 107 fragile sites are given, together with their gene symbols, frequency, mode of induction, and status. The majority of these fragile sites are common ones induced to expression by aphidicolin. Fragile sites are nonrandomly distributed within the genome. Chromosome 3 is especially short of known fragile sites. Chromosome 21, the chromosome triplicated in Down syndrome, has no known fragile sites.
这是一份关于107个脆性位点的指南，这些位点均在1988年举行的最新一届人类基因定位国际研讨会（HGM 9.5）上被纳入考量。文中给出了所有107个脆性位点的染色体带位置，以及它们的基因符号、频率、诱导方式和状态。这些脆性位点中的大多数是常见的，可被阿非迪霉素诱导表达。脆性位点在基因组内呈非随机分布。3号染色体尤其缺乏已知的脆性位点。21号染色体是唐氏综合征中三倍体化的染色体，目前尚无已知的脆性位点。
