• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Evidence for an ancestral alphoid domain on the long arm of human chromosome 2.

作者信息

Avarello R, Pedicini A, Caiulo A, Zuffardi O, Fraccaro M

机构信息

Istituto di Biologia Generale e Genetica Medica, Università di Pavia, Italy.

出版信息

Hum Genet. 1992 May;89(2):247-9. doi: 10.1007/BF00217134.

DOI:10.1007/BF00217134
PMID:1587535
Abstract

In situ hybridization, under low stringency conditions with two alphoid DNA probes (pY alpha 1 and p82H) labeled with digoxigenin-dUTP, decorated all the centromeres of the human karyotype. However, signals were also detected on the long arm of chromosome 2 at approximately q21.3-q22.1. Since it is supposed that human chromosome 2 originated by the telomeric fusion of two ancestral primate chromosomes, these findings indicate that not only the telomeric sequences, but also the ancestral centromere (or at least its alphoid sequences), have been conserved.

摘要

相似文献

1
Evidence for an ancestral alphoid domain on the long arm of human chromosome 2.
Hum Genet. 1992 May;89(2):247-9. doi: 10.1007/BF00217134.
2
Organization and genomic distribution of "82H" alpha satellite DNA. Evidence for a low-copy or single-copy alphoid domain located on human chromosome 14.“82H”α卫星DNA的组织与基因组分布。位于人类14号染色体上的低拷贝或单拷贝α卫星结构域的证据。
Hum Genet. 1988 Jan;78(1):27-32. doi: 10.1007/BF00291229.
3
PCR amplification and simultaneous digoxigenin incorporation of long DNA probes for fluorescence in situ hybridization.用于荧光原位杂交的长DNA探针的PCR扩增及地高辛同时掺入
Biotechniques. 1992 Jan;12(1):98-102.
4
Isolation and comparative mapping of a human chromosome 20-specific alpha-satellite DNA clone.人类20号染色体特异性α-卫星DNA克隆的分离与比较定位
Cytogenet Cell Genet. 1992;59(1):12-6. doi: 10.1159/000133188.
5
Comparative mapping of human alphoid sequences in great apes using fluorescence in situ hybridization.利用荧光原位杂交技术对大猩猩中的人类α卫星序列进行比较定位。
Genomics. 1995 Jan 20;25(2):477-84. doi: 10.1016/0888-7543(95)80048-q.
6
Absence of satellite III DNA in the centromere and the proximal long-arm region of human chromosome 14: analysis of a 14p- variant.
Cytogenet Cell Genet. 1992;61(1):78-80. doi: 10.1159/000133373.
7
p82H identifies sequences at every human centromere.p82H可识别每个人类着丝粒处的序列。
Hum Genet. 1987 Sep;77(1):46-50. doi: 10.1007/BF00284712.
8
Structural rearrangements and insertions of dispersed elements in pericentromeric alpha satellites occur preferably at kinkable DNA sites.着丝粒周围α卫星中分散元件的结构重排和插入，优先发生在可弯曲DNA位点。
J Mol Biol. 2001 Jan 5;305(1):33-48. doi: 10.1006/jmbi.2000.4270.
9
Concerted evolution of alpha satellite DNA: evidence for species specificity and a general lack of sequence conservation among alphoid sequences of higher primates.α卫星DNA的协同进化：高等灵长类动物α卫星序列中物种特异性及普遍缺乏序列保守性的证据。
Chromosoma. 1989 Oct;98(4):273-9. doi: 10.1007/BF00327313.
10
Three-way and two-way rearrangements involving chromosomes 10, 2, 5 and 5, 2 in two marker chromosomes of a human melanoma cell line.
Melanoma Res. 1994 Aug;4(4):259-65. doi: 10.1097/00008390-199408000-00008.

引用本文的文献

1
PhaseDancer: a novel targeted assembler of segmental duplications unravels the complexity of the human chromosome 2 fusion going from 48 to 46 chromosomes in hominin evolution.PhaseDancer：一种新型的靶向片段重复组装体，揭示了人类染色体 2 融合的复杂性，从同源人的 48 条染色体到 46 条染色体。
Genome Biol. 2023 Sep 11;24(1):205. doi: 10.1186/s13059-023-03022-8.
2
Alpha Satellite Insertion Close to an Ancestral Centromeric Region.α 卫星插入临近一个祖先着丝粒区。
Mol Biol Evol. 2021 Dec 9;38(12):5576-5587. doi: 10.1093/molbev/msab244.
3
Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability .

本文引用的文献

1
[Comparison of the structure of chromatids of Homo sapiens and Pan troglodytes (author's transl)].智人与黑猩猩染色单体结构的比较（作者译）
Chromosoma. 1973;43(4):423-44. doi: 10.1007/BF00406748.
2
Telomeric repeat from T. thermophila cross hybridizes with human telomeres.嗜热栖热菌的端粒重复序列与人类端粒发生交叉杂交。
Nature. 1988 Apr 14;332(6165):656-9. doi: 10.1038/332656a0.
3
Organization and genomic distribution of "82H" alpha satellite DNA. Evidence for a low-copy or single-copy alphoid domain located on human chromosome 14.
独立机制导致霍奇金淋巴瘤的基因组不稳定：微卫星或染色体不稳定
Cancers (Basel). 2018 Jul 13;10(7):233. doi: 10.3390/cancers10070233.
4
Transmission of Induced Chromosomal Aberrations through Successive Mitotic Divisions in Human Lymphocytes after In Vitro and In Vivo Radiation.体外和体内辐射后人类淋巴细胞中诱导染色体畸变通过连续有丝分裂传递。
Sci Rep. 2017 Jun 12;7(1):3291. doi: 10.1038/s41598-017-03198-7.
5
Centromere Destiny in Dicentric Chromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region.双着丝粒染色体中的着丝粒命运：来自人类2号染色体祖先着丝粒区域进化的新见解
Mol Biol Evol. 2017 Jul 1;34(7):1669-1681. doi: 10.1093/molbev/msx108.
6
Ribosomal RNA Genes Contribute to the Formation of Pseudogenes and Junk DNA in the Human Genome.核糖体RNA基因对人类基因组中假基因和垃圾DNA的形成有贡献。
Genome Biol Evol. 2017 Feb 1;9(2):380-397. doi: 10.1093/gbe/evw307.
7
One pedigree we all may have come from - did Adam and Eve have the chromosome 2 fusion?我们可能都来自同一个谱系——亚当和夏娃有2号染色体融合吗？
Mol Cytogenet. 2016 Sep 26;9:72. doi: 10.1186/s13039-016-0283-3. eCollection 2016.
8
Centromere inactivation on a neo-Y fusion chromosome in threespine stickleback fish.三刺鱼新Y融合染色体上的着丝粒失活
Chromosome Res. 2016 Dec;24(4):437-450. doi: 10.1007/s10577-016-9535-7. Epub 2016 Aug 23.
9
Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.有丝分裂优先在着丝粒区域和端粒融合处打断双着丝粒染色体。
Genes Dev. 2015 Feb 1;29(3):322-36. doi: 10.1101/gad.254664.114.
10
Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes.肺脏间充质干细胞、肺上皮细胞、气道细胞、间充质干细胞和淋巴细胞中2号和3号染色体基因表达谱的变化。
J Cell Mol Med. 2014 Oct;18(10):2044-60. doi: 10.1111/jcmm.12429. Epub 2014 Oct 2.
“82H”α卫星DNA的组织与基因组分布。位于人类14号染色体上的低拷贝或单拷贝α卫星结构域的证据。
Hum Genet. 1988 Jan;78(1):27-32. doi: 10.1007/BF00291229.
4
Structure of the major block of alphoid satellite DNA on the human Y chromosome.
J Mol Biol. 1987 Jun 5;195(3):457-70. doi: 10.1016/0022-2836(87)90175-6.
5
Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation.特定序列的缺失或着丝粒染色质的修饰是Y染色体着丝粒失活的原因。
Hum Genet. 1990 Oct;85(5):491-4. doi: 10.1007/BF00194222.
6
A guide to fragile sites on human chromosomes.人类染色体脆性位点指南。
Cancer Genet Cytogenet. 1990 Jan;44(1):37-45. doi: 10.1016/0165-4608(90)90195-g.
7
Homology between human and simian repeated DNA.人类与猿猴重复DNA之间的同源性。
Nature. 1978 Nov 2;276(5683):92-4. doi: 10.1038/276092a0.