口服避孕药、生育史与欧洲癌症与营养前瞻性调查中的结直肠癌风险。
Oral contraceptives, reproductive history and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.
机构信息
Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, OX3 7LF Oxford, UK.
出版信息
Br J Cancer. 2010 Nov 23;103(11):1755-9. doi: 10.1038/sj.bjc.6605965. Epub 2010 Nov 2.
BACKGROUND
Oral contraceptive use and reproductive factors may initiate long-term changes to the hormonal milieu and thereby, possibly influence colorectal cancer risk.
METHODS
We examined the association of hormonal and reproductive factors with risk of colorectal cancer among 337,802 women in the European Prospective Investigation into Cancer and Nutrition, of whom 1878 developed colorectal cancer.
RESULTS
After stratification for center and age, and adjustment for body mass index, smoking, diabetes mellitus, physical activity and alcohol consumption, ever use of oral contraceptives was marginally inversely associated with colorectal cancer risk (hazard ratio (HR), 0.92; 95% confidence interval (CI), 0.83-1.02), although this association was stronger among post-menopausal women (HR, 0.84; 95% CI: 0.74-0.95). Duration of oral contraceptive use and reproductive factors, including age at menarche, age at menopause, type of menopause, ever having an abortion, parity, age at first full-term pregnancy and breastfeeding, were not associated with colorectal cancer risk.
CONCLUSION
Our findings provide limited support for a potential inverse association between oral contraceptives and colorectal cancer risk.
背景
口服避孕药的使用和生殖因素可能会引发激素环境的长期变化，从而可能影响结直肠癌的风险。
方法
我们研究了激素和生殖因素与欧洲癌症与营养前瞻性调查中的 337802 名女性中结直肠癌风险之间的关联，其中 1878 人患有结直肠癌。
结果
在按中心和年龄分层以及调整体重指数、吸烟、糖尿病、体力活动和饮酒后，口服避孕药的使用与结直肠癌风险呈轻微负相关（风险比 (HR)，0.92；95%置信区间 (CI)，0.83-1.02），尽管这种关联在绝经后妇女中更强（HR，0.84；95%CI：0.74-0.95）。口服避孕药的使用时间和生殖因素，包括初潮年龄、绝经年龄、绝经类型、是否流产、产次、首次足月妊娠年龄和母乳喂养时间，与结直肠癌风险无关。
结论
我们的研究结果为口服避孕药与结直肠癌风险之间可能存在的负相关提供了有限的支持。
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