肌动蛋白向动力蛋白脱帽致敬。
Actin takes its hat off to dynamin.
机构信息
Department of Biochemistry, Science II, University of Geneva, Geneva, Switzerland.
出版信息
EMBO J. 2010 Nov 3;29(21):3591-2. doi: 10.1038/emboj.2010.263.
Abstract
The large GTPase dynamin is a major player in membrane traffic, but it is also known for its indirect association with the actin cytoskeleton via actin-binding proteins like cortactin. In this issue of The Gu and co-workers reveal a direct interaction between dynamin and F-actin and demonstrate that oligomerized dynamin promotes the removal of the gelsolin cap at filament barbed ends.
摘要
大型 GTP 酶 dynamin 是膜运输的主要参与者，但它也因其与肌动蛋白细胞骨架的间接关联而闻名，这种关联是通过像 cortactin 这样的肌动蛋白结合蛋白实现的。在本期《 》杂志中，顾和他的同事们揭示了 dynamin 与 F-actin 之间的直接相互作用，并证明了寡聚化的 dynamin 促进了细丝帽状末端的凝胶蛋白盖帽的去除。
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本文引用的文献
1
Direct dynamin-actin interactions regulate the actin cytoskeleton.直接的动力蛋白-肌动蛋白相互作用调节肌动蛋白细胞骨架。
EMBO J. 2010 Nov 3;29(21):3593-606. doi: 10.1038/emboj.2010.249. Epub 2010 Oct 8.
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Mechanical requirements for membrane fission: common facts from various examples.膜裂变的力学要求：来自各种实例的共同事实。
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Beginning and ending an actin filament: control at the barbed end.肌动蛋白丝的起始与终止：对带刺末端的调控
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