Department of Neonatology, University Hospital Maternity Ward of the Canary Islands, Las Palmas, Spain.
Eur J Pediatr. 2011 Apr;170(4):531-4. doi: 10.1007/s00431-010-1339-8. Epub 2010 Nov 3.
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
先天性白血病是一种罕见疾病，具有独特的生物学和临床特征，与年长儿童和成人的白血病不同。在这里，我们描述了两名具有不同临床表现（白血病皮肤浸润与脾肿大和呼吸窘迫）和致命结局的新生儿先天性急性淋巴细胞白血病病例。两个病例均表达髓样抗原（CD65）和涉及 MLL 基因（位于 11q23）的细胞遗传学异常，与极差的预后相关。
