Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.
Endocrine. 2010 Oct;38(2):206-13. doi: 10.1007/s12020-010-9374-9. Epub 2010 Jul 11.
Metabolic syndrome (MetS), manifested by insulin resistance, dyslipidemia, central obesity, and hypertension, is conceived to be associated with hyperleptinemia and physical activity. The aim of this study was to elucidate the factors underlying components of MetS and also to test the suitability of leptin and physical activity as additional components of this syndrome. Data of the individuals without history of diabetes mellitus, aged 25-64 years, from third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007), were analyzed. Performing factor analysis on waist circumference, homeostasis model assessment of insulin resistance, systolic blood pressure, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) led to extraction of two factors which explained around 59.0% of the total variance in both genders. When TG and HDL-C were replaced by TG to HDL-C ratio, a single factor was obtained. In contrast to physical activity, addition of leptin was consistent with one-factor structure of MetS and improved the ability of suggested models to identify obesity (BMI≥30 kg/m2, P<0.01), using receiver-operator characteristics curve analysis. In general, physical activity loaded on the first identified factor. Our study shows that one underlying factor structure of MetS is also plausible and the inclusion of leptin does not interfere with this structure. Further, this study suggests that physical activity influences MetS components via modulation of the main underlying pathophysiologic pathway of this syndrome.
代谢综合征（MetS）表现为胰岛素抵抗、血脂异常、中心性肥胖和高血压，被认为与高瘦素血症和身体活动有关。本研究旨在阐明代谢综合征各成分的相关因素，并检验瘦素和身体活动作为该综合征附加成分的适宜性。对无糖尿病史、年龄在 25-64 岁的人群进行了第三次非传染性疾病危险因素国家监测（SuRFNCD-2007）的数据进行了分析。对腰围、稳态模型评估的胰岛素抵抗、收缩压、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）进行因子分析，提取出两个因子，这两个因子在两性中解释了大约 59.0%的总方差。当 TG 和 HDL-C 被 TG 与 HDL-C 的比值取代时，得到一个单一的因子。与身体活动不同，瘦素的加入与代谢综合征的单因素结构一致，并通过接受者操作特征曲线分析，改善了所建议模型识别肥胖（BMI≥30kg/m2，P<0.01）的能力。一般来说，身体活动加载在第一个确定的因子上。我们的研究表明，代谢综合征的一个潜在的单一结构也是合理的，瘦素的加入并不干扰这种结构。此外，本研究表明，身体活动通过调节该综合征主要潜在病理生理途径来影响代谢综合征成分。
