免疫球蛋白重链类别转换重组的拷贝选择机制。
Copy choice mechanism of immunoglobulin heavy-chain switch recombination.
作者信息
Dunnick W, Stavnezer J
机构信息
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620.
出版信息
Mol Cell Biol. 1990 Jan;10(1):397-400. doi: 10.1128/mcb.10.1.397-400.1990.
Abstract
The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.
摘要
免疫球蛋白重链转换由与供体和受体恒定区基因相关的DNA转换区域之间的重组事件介导。我们已经确定，重组后在某些转换区域中发现的突变似乎仅出现在DNA的一条链上。这一结果表明，转换重组涉及一条DNA链的易错合成以及另一条链与预先存在的DNA的连接。
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