免疫球蛋白重链类别转换重组的拷贝选择机制。
Copy choice mechanism of immunoglobulin heavy-chain switch recombination.
作者信息
Dunnick W, Stavnezer J
机构信息
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620.
出版信息
Mol Cell Biol. 1990 Jan;10(1):397-400. doi: 10.1128/mcb.10.1.397-400.1990.
Abstract
The immunoglobulin heavy-chain switch is mediated by a recombination event between DNA switch regions associated with donor and recipient constant-region genes. We have determined that the mutations which can be found in some switch regions after recombination appear to arise on only one strand of DNA. This result suggests that switch recombination involves error-prone synthesis of one DNA strand and ligation of the other strand from preexisting DNA.
摘要
免疫球蛋白重链转换由与供体和受体恒定区基因相关的DNA转换区域之间的重组事件介导。我们已经确定，重组后在某些转换区域中发现的突变似乎仅出现在DNA的一条链上。这一结果表明，转换重组涉及一条DNA链的易错合成以及另一条链与预先存在的DNA的连接。
相似文献
1
Copy choice mechanism of immunoglobulin heavy-chain switch recombination.免疫球蛋白重链类别转换重组的拷贝选择机制。
Mol Cell Biol. 1990 Jan;10(1):397-400. doi: 10.1128/mcb.10.1.397-400.1990.
2
Class switch from mu to delta is mediated by homologous recombination between sigma mu and sigma mu sequences in human immunoglobulin gene loci.从μ到δ的类别转换是由人类免疫球蛋白基因座中σμ和σμ序列之间的同源重组介导的。
Eur J Immunol. 1989 Aug;19(8):1399-403. doi: 10.1002/eji.1830190808.
3
Circular DNA is a product of the immunoglobulin class switch rearrangement.环状DNA是免疫球蛋白类别转换重排的产物。
Nature. 1990 May 31;345(6274):452-6. doi: 10.1038/345452a0.
4
Nonhomologous recombination at sites within the mouse JH-C delta locus accompanies C mu deletion and switch to immunoglobulin D secretion.小鼠JH-Cδ基因座内位点的非同源重组伴随着Cμ缺失并转换为免疫球蛋白D分泌。
Mol Cell Biol. 1991 Nov;11(11):5660-70. doi: 10.1128/mcb.11.11.5660-5670.1991.
5
6
Anomalous rearrangements of the immunoglobulin heavy chain genes in human leukemias support the loop-out mechanism of class switch.人类白血病中免疫球蛋白重链基因的异常重排支持类别转换的环出机制。
J Clin Invest. 1992 Dec;90(6):2299-303. doi: 10.1172/JCI116117.
7
Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals.从非洲爪蟾到哺乳动物的免疫球蛋白类别转换重组断点的微位点。
Eur J Immunol. 1997 Oct;27(10):2610-9. doi: 10.1002/eji.1830271021.
8
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.通过Cre-loxP介导的基因靶向作用证明在各个转换区对免疫球蛋白转换重组的独立控制。
Cell. 1993 Jun 18;73(6):1155-64. doi: 10.1016/0092-8674(93)90644-6.
9
Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.免疫球蛋白重链类别转换的环出和缺失机制。
Proc Natl Acad Sci U S A. 1988 Mar;85(5):1581-5. doi: 10.1073/pnas.85.5.1581.
10
S gamma 3 SNIP and SNAP binding motifs are occupied in vivo in mitogen-activated I.29 mu + cells.
Curr Top Microbiol Immunol. 1995;194:431-8. doi: 10.1007/978-3-642-79275-5_50.
引用本文的文献
1
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.DNA聚合酶η的缺失揭示了免疫球蛋白转换区非转录链上C突变的靶向作用。
J Exp Med. 2004 Apr 5;199(7):917-24. doi: 10.1084/jem.20032022. Epub 2004 Mar 29.
2
Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor.定义μ→γ3类别转换重组的同种型特异性的功能性重组基序的定位表明NF-κB p50是同种型特异性转换因子。
J Exp Med. 2004 Mar 1;199(5):617-27. doi: 10.1084/jem.20031935.
3
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.突变发生在Ig Smu区域，但在类别转换重排之前很少发生在Sgamma区域。
EMBO J. 2003 Nov 3;22(21):5893-903. doi: 10.1093/emboj/cdg550.
4
DNA-dependent protein kinase activity is not required for immunoglobulin class switching.免疫球蛋白类别转换不需要依赖DNA的蛋白激酶活性。
J Exp Med. 2002 Dec 2;196(11):1483-95. doi: 10.1084/jem.20001871.
5
Internal IgH class switch region deletions are position-independent and enhanced by AID expression.内部免疫球蛋白重链类别转换区缺失与位置无关，并由激活诱导的胞苷脱氨酶（AID）表达增强。
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. doi: 10.1073/pnas.152333499. Epub 2002 Jul 11.
6
The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.活化诱导胞嘧啶脱氨酶（AID）在体细胞高频突变和类别转换重组中的作用：DNA断裂的上游还是下游
J Exp Med. 2002 May 6;195(9):F37-41. doi: 10.1084/jem.20020380.
7
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.活化诱导的脱氨酶在体细胞超突变过程的切割后步骤中发挥作用。
J Exp Med. 2002 May 6;195(9):1193-8. doi: 10.1084/jem.20011858.
8
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.μ转换区串联重复序列对于抗体类别转换重组很重要，但并非必需。
J Exp Med. 2001 Jan 15;193(2):159-68. doi: 10.1084/jem.193.2.159.
9
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.错配修复酶缺陷小鼠脾脏B细胞中同种型转换减少。
J Exp Med. 1999 Aug 2;190(3):323-30. doi: 10.1084/jem.190.3.323.
10
The liaison of isotype class switch and mismatch repair: an illegitimate affair.同种型类别转换与错配修复的关联：一段不正当的关系。
J Exp Med. 1999 Aug 2;190(3):307-10. doi: 10.1084/jem.190.3.307.
本文引用的文献
1
2
Rearrangements between the immunoglobulin heavy chain gene JH and C mu regions accompany normal B lymphocyte differentiation in vitro.免疫球蛋白重链基因JH和Cμ区域之间的重排伴随着体外正常B淋巴细胞的分化。
Nature. 1982 Oct 21;299(5885):742-4. doi: 10.1038/299742a0.
3
A model for the molecular requirements of immunoglobulin heavy chain class switching.免疫球蛋白重链类别转换分子需求的模型。
Nature. 1982 Jul 1;298(5869):87-9. doi: 10.1038/298087a0.
4
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes.免疫球蛋白重链基因类别转换重组区域中的重复序列。
Cell. 1981 Feb;23(2):357-68. doi: 10.1016/0092-8674(81)90131-8.
5
DNA sequences mediating class switching in alpha-immunoglobulins.介导α-免疫球蛋白类别转换的DNA序列。
Science. 1980 Sep 19;209(4463):1360-5. doi: 10.1126/science.6774415.
6
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.产生完整的免疫球蛋白重链基因需要两种类型的体细胞重组。
Nature. 1980 Aug 14;286(5774):676-83. doi: 10.1038/286676a0.
7
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing.一种对重链转换和RNA剪接有影响的免疫球蛋白缺失突变体。
Nature. 1980 Aug 14;286(5774):669-75. doi: 10.1038/286669a0.
8
Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression.恒定区基因座的缺失可解释免疫球蛋白重链表达的转换。
Nature. 1980 Jun 12;285(5765):450-6. doi: 10.1038/285450a0.
9
Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells.通过对小鼠浆细胞瘤细胞的研究揭示B淋巴细胞发育过程中免疫球蛋白重链基因的重排。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1422-6. doi: 10.1073/pnas.77.3.1422.
10
An immunoglobulin heavy-chain gene is formed by at least two recombinational events.一个免疫球蛋白重链基因由至少两个重组事件形成。
Nature. 1980 Feb 21;283(5749):733-9. doi: 10.1038/283733a0.
Zotero 插件