Paediatric Research Centre, University of Tampere, Tampere, Finland.
Pediatr Infect Dis J. 2010 Nov;29(11):1013-5.
Preliminary evidence suggests that viral-pertussis coinfections are common in nonvaccinated infants.
Bordetella pertussis infection was studied by polymerase chain reaction in nasopharyngeal aspirates in 142 infants <6 months of age, who were admitted for bronchiolitis. Viral etiology,documented by antigen detection or polymerase chain reaction in nasopharyngeal aspirate, was respiratory syncytial virus (RSV) in 105, rhinovirus in 8, influenza A virus in 8, and other viruses in 10 cases. Only 11 samples were negative.
B. pertussis infection was found in 12 (8.5%) cases, being coinfection with RSV in 8 (67%) cases (7.6% of all RSV infections). In a retrospective analysis, RSV-pertussis coinfections and sole RSV infections did not differ for the presence of cough. Preliminary evidence was found that a history of coughing spells was associated with B. pertussis identification.
Coinfection with B. pertussis was present in 8.5% of <6-month-old infants, who were hospitalized for viral bronchiolitis. To avoid underdiagnosis, pertussis should be considered in all nonvaccinated infants admitted for lower respiratory tract infection.
初步证据表明，未接种疫苗的婴儿中，百日咳病毒与其他病毒的合并感染较为常见。
142 名 6 月龄以下因毛细支气管炎住院的婴儿，通过聚合酶链反应（PCR）检测鼻咽抽吸物中的百日咳博德特氏菌感染情况。通过抗原检测或 PCR 检测鼻咽抽吸物确定病毒病因，其中呼吸道合胞病毒（RSV）105 例，鼻病毒 8 例，甲型流感病毒 8 例，其他病毒 10 例。仅 11 例结果为阴性。
12 例（8.5%）婴儿检测出百日咳博德特氏菌感染，8 例（67%）为与 RSV 的合并感染（所有 RSV 感染的 7.6%）。在回顾性分析中，RSV-百日咳合并感染和单纯 RSV 感染在咳嗽症状的存在上无差异。有证据表明，阵咳病史与百日咳博德特氏菌的鉴定有关。
因病毒性毛细支气管炎住院的 6 月龄以下婴儿中，8.5%存在百日咳博德特氏菌合并感染。为避免漏诊，所有未接种疫苗的下呼吸道感染住院婴儿均应考虑百日咳。
