Meqdam Mamdoh M, Subaih Sami H
Department of Medical Microbiology, Al-Qassim University, Al-Qassim, Saudi Arabia.
FEMS Immunol Med Microbiol. 2006 Jun;47(1):129-33. doi: 10.1111/j.1574-695X.2006.00073.x.
During December to the end of February of 2003 and 2004, a total of 282 nasopharyngeal aspirates were obtained from infants and young children admitted to the Buraidah Maternity and Pediatric Hospital, Al-Qassim, Saudi Arabia, and clinically diagnosed as suffering from acute lower respiratory tract infections. The aspirates were tested for the presence of respiratory syncytial virus using direct fluorescein-labeled monoclonal antibody assay. Of the 282 specimens, 128 (45.4%) were found to be positive for respiratory syncytial virus. The most positive specimens came from patients less than one year old (51.3%), and were associated with bronchopneumonia (56.7%) or bronchiolits (55.4%). Coughing (100%) and tachpnea (98%) were significantly more frequent in infants with respiratory syncytial virus infection, followed by wheezing, crepitation and retraction, each representing 66%. Three deaths were reported. The availability of a rapid viral diagnostic assay will be an important tool for physicians to make more accurate treatment decisions and therefore reduce unnecessary antibiotic usage and hospital stay for the patients.
在2003年12月至2004年2月底期间，从沙特阿拉伯卡西姆省布赖代妇产儿童医院收治的婴幼儿中总共采集了282份鼻咽抽吸物，这些婴幼儿临床诊断为患有急性下呼吸道感染。使用直接荧光素标记单克隆抗体检测法对这些抽吸物进行呼吸道合胞病毒检测。在282份标本中，有128份（45.4%）被检测出呼吸道合胞病毒呈阳性。阳性标本大多来自1岁以下的患者（51.3%），且与支气管肺炎（56.7%）或细支气管炎（55.4%）有关。呼吸道合胞病毒感染的婴儿咳嗽（100%）和呼吸急促（98%）的发生率明显更高，其次是喘息、捻发音和吸气凹陷，各占66%。报告了3例死亡病例。快速病毒诊断检测方法的应用将成为医生做出更准确治疗决策的重要工具，从而减少患者不必要的抗生素使用和住院时间。
