Chen Sainan, Wang Yuqing, Li Anrong, Jiang Wujun, Xu Qiuyan, Wu Min, Chen Zhengrong, Hao Chuangli, Shao Xunjun, Xu Jun
Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, China.
Department of Pediatrics, Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, China.
Front Pediatr. 2021 Aug 12;9:621381. doi: 10.3389/fped.2021.621381. eCollection 2021.
In recent years, the incidence of infection in infants and young children has been increasing. Multiple studies have suggested that may be one of the pathogens of bronchiolitis in infants and young children. However, the prevalence and clinic characteristic of in bronchiolitis is controversial. This prospective descriptive study evaluated the prevalence and clinical manifestations of infants and young children hospitalized for bronchiolitis with . Children hospitalized with bronchiolitis were eligible for a prospective study for 36 months from January 1, 2017, to December 31, 2019. Besides , 10 common respiratory viruses and (MP) were confirmed by laboratory tests. Medical records of patients were reviewed for demographic, clinical characteristics, and laboratory examination. A total of 1,092 patients with bronchiolitis were admitted. was detected in 78/1,092 (7.1%) patients. Of the 78 patients with bronchiolitis, coinfections occurred in 45 (57.7%) patients, most frequently with human rhinovirus (28/78, 35.9%), followed by MP (9/78, 11.4%), and human bocavirus (6/78, 7.7%). The peak incidence of infection was in May. A high leukocyte count could help distinguish associated acute bronchiolitis from other acute bronchiolitis etiologies. After excluding coinfections, children with only bronchiolitis exhibited a milder clinical presentation than those with RSV-only infection; also, children with MP-only and other pathogen infections revealed similar severity. The morbidity of was common (31/78, 39.7%) in infants with bronchiolitis under 3 months. In summary, is one of the pathogens in children with bronchiolitis, and coinfection of with other viruses is common in bronchiolitis. should be considered when patients hospitalized with bronchiolitis present a longer course and have an elevated leukocyte count. Patients with associated bronchiolitis present a milder clinical presentation.
近年来，婴幼儿感染的发生率一直在上升。多项研究表明，[具体病原体名称未给出]可能是婴幼儿细支气管炎的病原体之一。然而，[具体病原体名称未给出]在细支气管炎中的患病率和临床特征存在争议。这项前瞻性描述性研究评估了因[具体病原体名称未给出]感染而住院的婴幼儿的患病率和临床表现。2017年1月1日至2019年12月31日期间，因细支气管炎住院的儿童符合一项为期36个月的前瞻性研究条件。除了[具体病原体名称未给出]外，通过实验室检测确诊了10种常见呼吸道病毒和肺炎支原体（MP）。查阅患者的病历以获取人口统计学、临床特征和实验室检查信息。共有1092例细支气管炎患者入院。在1092例患者中有78例（7.1%）检测到[具体病原体名称未给出]。在78例[具体病原体名称未给出]细支气管炎患者中，45例（57.7%）发生了合并感染，最常见的是与人类鼻病毒合并感染（28/78，35.9%），其次是肺炎支原体（9/78，11.4%）和人博卡病毒（6/78，7.7%）。[具体病原体名称未给出]感染的高峰发病率在5月。白细胞计数升高有助于将相关的急性细支气管炎与其他急性细支气管炎病因区分开来。排除合并感染后，仅患有细支气管炎的儿童临床表现比仅感染呼吸道合胞病毒（RSV）的儿童更轻；此外，仅感染肺炎支原体和其他病原体感染的儿童病情严重程度相似。在3个月以下患有细支气管炎的婴儿中，[具体病原体名称未给出]的发病率很常见（31/78，39.7%）。总之，[具体病原体名称未给出]是细支气管炎患儿的病原体之一，并且在细支气管炎中[具体病原体名称未给出]与其他病毒的合并感染很常见。当因细支气管炎住院的患者病程较长且白细胞计数升高时，应考虑[具体病原体名称未给出]感染。伴有[具体病原体名称未给出]的细支气管炎患者临床表现较轻。
